Utilización de antidiabéticos en un área de salud urbana y otra rural de la provincia de Valencia / No disponible

Se realiza un estudio ecológico descriptivo de datos agregados de prescripción, cuyo objetivo es comprobarsi las distintas características sociodemográficas y asistenciales de un área de salud urbana y otra ruralcondicionan el uso de antidiabéticos.Material y métodos: El periodo de estudio abarca de enero de 2002 hasta diciembre de 2004. El consumo demedicamentos se expresa en dosis diaria definida por 1.000 habitantes y día estandarizada (DHD stand).Se realiza un análisis comparativo entre las dos áreas de salud de los subgrupos terapéuticos A10A, A10BA,A10BB, A10BG, A10BX y A10BF.Resultados: Al finalizar el periodo analizado, se aprecia un fuerte ascenso de la metformina, que a principios del periodo de estudio representaba, respecto al total de antidiabéticos orales (AO), el 11,2% en el área rural y el 15,3% en el área urbana, y en el último trimestre de 2004, el 24,4% en el área rural y el 24,6% en la urbana. El cociente insulinas/AO se mantuvo en el área urbana en 0,36-0,35, justo el doble que el valor0,18 del área rural.Conclusiones: El trabajo confirma que en un área rural el uso relativo de medicamentos antidiabéticoses mayor que en un área urbana y constata, en ambas áreas, un fuerte ascenso de la metformina, con unamayor adecuación a las guías de práctica clínica. Sin embargo, existe una menor utilización de insulina enel área rural, por lo que sería interesante realizar un estudio analítico posterior para confirmar la hipótesisde un uso insuficiente de insulinoterapia y/o excesivo de AO en el área rural

Objective: The authors performed a descriptive ecological study based on aggregate prescription data. The purpose was to determine whether the different sociodemographic characteristics and health care needs of an urban and a rural health area influence the use of antidiabetic agents.Material and methods: The study was carried out from January 2002 to December 2004. The consumptionof medications was expressed in standardized defined daily doses per 1000 population and day (standDDD). The two health areas were compared to determine the differences between therapeutic subgroups A10A,A10BA, A10BB, A10BG, A10BX andA10BF.Results: By the end of the study period, there was a marked increase in the prescription of metformin which,at the beginning of the study, had represented 11.2% of all oral antidiabetic agents consumed in the rural areaand 15.3% in the urban area. In the last quarter of 2004, these values were 24.4% in the rural area and 24.6%in the urban area. The ratio of insulin to oral antidiabetic agents in the urban area remained at 0.36-0.35,exactly twice that of the rural area, where it was 0.18.Conclusions: This study confirms the fact that, in the rural area, the relative use of antidiabetic agentsis greater than in the urban area, and demonstrates, in both areas, a marked increase in the prescriptionof metformin, with a greater adaptation to the clinical practice guidelines. However, insulin is less widelyadministered in the rural area. For this reason, it might be of interest to carry out a subsequent analyticalstudy to confirm the hypothesis concerning the underutilization of insulin therapy and/or overuse of oral antidiabetic agents in the rural area.

Spectrophotometric determination of the theophylline in plasma by the apparent content curves method.

A direct spectrophotometric procedure for the determination of theophylline in plasma is proposed. This procedure is based on the apparent content curves method and it is not necessary to know the nature and contents of interferent substances. Bias errors introduced by plasma and metabolites are avoided. The results obtained are in agreement with those provided by an immunofluoroassay used as a reference method.