RESUMO
This report describes an azoospermic male carrying a Y/autosome translocation. The patient had a 46,X,t(Y;10)(q12;p13) chromosome complement in a lymphocyte culture. The cytogenetic study of this patient is described, together with testicular histology, spermiogram, hormone levels, and clinical history.
Assuntos
Cromossomos Humanos 6-12 e X , Oligospermia/genética , Cromossomos Sexuais , Translocação Genética , Cromossomo Y , Adulto , Bandeamento Cromossômico , Humanos , Masculino , Fenótipo , Testículo/anatomia & histologiaRESUMO
Two brothers have spermiograms with a similar pattern: absolute teratozoospermia with round-headed spermatozoa. The familial trait only has been previously one time in the literature. The spermatozoa show several abnormalities in the head. They lack acrosome and postacrosomal sheath. The nuclei are small and the chromatin is distributed in small groups. The nuclear envelope has abundant pores and is loosely attached to the chromatin. All the nuclei have brown inclusions, refringent when they are observed under the light microscope, vesicular and laminar under the electron microscope. Other abnormalities less frequently observed are: irregularities in the mitochondrial sheath, loss of parallelism of the dense fibres and duplication and angulation of the sperm tail. The hormonal assays and the biochemical tests are normal in both patients.
Assuntos
Infertilidade Masculina/genética , Cabeça do Espermatozoide/ultraestrutura , Espermatozoides/ultraestrutura , Acrossomo/ultraestrutura , Adulto , Núcleo Celular/ultraestrutura , Cromatina/ultraestrutura , Humanos , Masculino , Mitocôndrias/ultraestrutura , Membrana Nuclear/ultraestrutura , Cauda do Espermatozoide/ultraestruturaAssuntos
Infertilidade Feminina , Infertilidade Masculina , Gravidez , Adulto , Fatores Etários , Gonadotropina Coriônica/uso terapêutico , Clomifeno/uso terapêutico , Feminino , Humanos , Infertilidade Feminina/tratamento farmacológico , Infertilidade Masculina/tratamento farmacológico , Masculino , Fatores de TempoRESUMO
The authors try to demonstrate a relation between the number of immature cells of germinal origin in sterile men's sperm and plasmatic gonadotrophin levels of the same patients. Plasma FSH, LH, testosterone and 17 beta-estradiol were assayed in two groups of male patients with teratospermia. Results were compared with those obtained in a control group of normal men. Hypophyseal gonadotrophins level is higher in men whose spermatogenesis is defective than in normal men. It is suggested that these results might support the hypothesis that a defect in inhibin synthesis would be responsible for raised gonadotrophins.
