[Structural and functional changes in sympathetic ganglia following endotoxin and alpha1-antitrypsin exposure]. / Strukturno-funktsional'nye izmeneniia v simpaticheskikh gangliiakh pri deistvii v organizme éndotoksina i al'fa-antitripsina.

Structural and functional organisation of sympathetic ganglia under conditions of endotoxemia was studied in white rats, cats, and dogs. Submicroscopic characteristics of the changes occurring in the rat prevertebral sympathetic ganglia after endotoxin administration or application of endogenous proteinase inhibitor alpha 1-antitrypsin, were assessed as well as ultrastructural bases of the febrile rat ganglionic responses to antipyretic drug administration. Effects of endotoxin on synaptic transmission in inferior mesenteric plexus' ganglia of cats and on electrical activity in inferior mesenteric plexus' ganglia of dogs, were electrophysiologically demonstrated.

[Role of proteinase inhibitors in the process that provide coupling between body's functional systems]. / O znachenii ingibitorov proteinaz v protsessakh, obespechivaiushchikh sopriazhenie deiatel'nosti funktsional'nykh sistem organizma.

The authors make an attempt to substantiate the idea that proteinase inhibitors can produce a noticeable effect on the integration of functions. It is suggested that proteinase inhibitors play a special role in providing coupling between the body's functional systems in the conditions that may disturb the structural and functional integrity of the organism. They paper provides experimental evidence for the effect of the serine proteinase inhibitor alpha 1-antitrypsin on the thermal regulatory system and couples functional systems that provide behavioral responses. Possible mechanisms of systemic action of proteinase inhibitors and their involvement in the integrative activity of the nervous system are discussed.