Generalization in Aphasia Treatment: A Tutorial for Speech-Language Pathologists.

PURPOSE: Generalization has been defined and instantiated in a variety of ways over the last half-century, and this lack of consistency has created challenges for speech-language pathologists to plan for, implement, and measure generalization in aphasia treatment protocols. This tutorial provides an overview of generalization with a focus on how it relates to aphasia intervention, including a synthesis of existing principles of generalization and examples of how these can be embedded in approaches to aphasia treatment in clinical and research settings. METHOD: Three articles collectively listing 20 principles of generalization formed the foundation for this tutorial. The seminal work of Stokes and Baer (1977) focused attention on generalization in behavioral change following treatment. Two aphasia-specific resources identified principles of generalization in relation to aphasia treatment (Coppens & Patterson, 2018; Thompson, 1989). A selective literature review was conducted to identify evidence-based examples of each of these 20 principles from the extant literature. RESULTS: Five principles of generalization were synthesized from the original list of 20. Each principle was supported by studies drawn from the aphasia treatment literature to exemplify its application. CONCLUSIONS: Generalization is an essential aspect of meaningful aphasia intervention. Successful generalization requires the same dedication to strategic planning and outcome measurement as the direct training aspect of intervention. Although not all people with aphasia are likely to benefit equally from each of the principles reviewed herein, our synthesis provides information to consider for maximizing generalization of aphasia treatment outcomes. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.24714399.

Novel participant-level meta-analytic evidence for AbSANT efficacy.

The current study employed interrupted time series (ITS) models to analyze all available (published and unpublished) Abstract Semantic Associative Network Training (AbSANT) data. AbSANT is a semantically focused anomia treatment that targets not only concrete but abstract words, unique among existing anomia treatments. However, evidence to date for the positive effects of AbSANT comes only from small-sample, single-subject design studies, limiting the strength of this evidence and the inferences that can be drawn from it. The statistical power and greater representativeness afforded by this larger aggregated sample enabled us to look for group-level efficacy evidence for AbSANT, examine specific questions about AbSANT's direct training and generalization effects, and identify potential predictors and mechanisms of AbSANT treatment response. We found that across 33 participants from four different data sources, AbSANT appears to be a robust word retrieval therapy protocol, with overall direct training and generalization effects that were more meaningful than exposure effects. Similar to previous smaller-sample study conclusions, we found that in this large sample, training abstract words results not only in larger direct training effects than training concrete words, but also larger generalization effects, suggesting that while AbSANT successfully improves both abstract and concrete word retrieval, it may be better suited for training abstract words. In general, direct training effects were more persistent after treatment ended than generalization effects and effects for concrete words were more persistent than for abstract words. Additionally, the effects of generalization appear to be distinct from the effects of simple exposure to words, and generalization effects are consistent with AbSANT's hypothesized mechanism of action: spreading activation from directly trained concepts to related concepts. Also consistent with this mechanism, we found that milder aphasia and both conceptual and lexical semantic processing ability predicted both direct training and generalization gains, and that executive function was predictive of generalization effects. These factors are thus important to consider when evaluating the appropriateness of AbSANT for individual clients.

Event related potential exploration of the organizational structure of abstract versus concrete words in neurologically intact younger adults.

The purpose of this study was to test the effects of concreteness and relationship type (similarity vs. association) on semantic processing using event-related potentials (ERP). Neurophysiological evidence has been found for the concreteness effect and for an effect of relationship type. This study replicated and extended these findings by investigating the interaction of concreteness and relationship type. Twenty-four neurologically healthy young adults performed lexical decision and semantic relatedness tasks while continuous scalp EEG was recorded. Larger N400 effects were found for concrete words in associative relationships than for concrete words in similarity relationships and abstract words in either type of relationship. The results are discussed in relation to the different representational frameworks account for abstract and concrete word processing.

Comprehension of Vernacular Features in Aphasia.

PURPOSE: Insights from linguistic variation research illustrate a linguistically diverse population, in which even speakers who can be classified as speaking a "mainstream" variety have grammatical knowledge of vernacular or "nonmainstream" features. However, there is a gap in our knowledge regarding how vernacular features are comprehended in people with aphasia (PWA). This article presents the results of a pilot study exploring how PWA respond to linguistic stimuli that include the vernacular feature, negative concord (NC), often referred to by the more colloquial term double negative (e.g., I didn't do nothing, equivalent to I didn't do anything). METHOD: Twelve PWA in the chronic stage of recovery each rated the naturalness and felicity of 48 critical sentences and 64 fillers, all of which contained two clauses, the second clause describing a consequence of the first. Ratings were analyzed using ordinal regression. RESULTS: PWA rated NC sentences as unacceptable, but felicitous-a pattern similar to that shown by neurologically intact adults in a previous study. CONCLUSIONS: These results suggest that PWA are sensitive to both social and linguistic information at levels similar to neurologically intact speakers. These results have implications for the integration of vernacular features into future research, assessment, and treatment protocols for PWA. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.19027322.

Counseling in Aphasia: Information and Strategies for Speech-Language Pathologists.

Purpose The purpose of this tutorial is to provide an overview of mental health concerns of persons with aphasia (PWAs), strategies that speech-language pathologists (SLPs) can use to address the mental health concerns of PWAs within their scope of practice, guidance related to how SLPs can help facilitate access to appropriate mental health services, and suggestions for the future of pre- and postcertification education regarding counseling in aphasia for SLPs. Method This tutorial begins with a case study that is used as a reference point throughout the tutorial. It then introduces the gap in mental health services for PWAs that prompted this work, walks SLPs through common mental health concerns PWAs experience, and provides guidance for SLPs related to counseling techniques they can utilize within their sessions and referral to counseling professionals. We end by reiterating the need for more mental health awareness and training for SLPs and suggestions for incorporating more training related to addressing client mental health concerns and developing effective collaborations with rehabilitation and mental health counselors, as needed. Conclusions The mental health needs of PWAs are not being met. This is partly due to a lack of training in counseling for SLPs and a lack of training in communication techniques for rehabilitation and mental health counselors. With this tutorial, we hope to bring more awareness to the current need for mental health services for PWAs and to provide SLPs with some tools for addressing these needs among their clientele.

Bilingual Abstract Semantic Associative Network Training (BAbSANT): A Polish-English case study.

INTRODUCTION: This article presents a novel approach to anomia therapy (i.e., BAbSANT: Bilingual Abstract Semantic Associative Network Training) for bilingual persons with aphasia (B-PWA) that capitalizes both on lexico-semantic theories in bilingualism and general theories of semantic organization and learning. Based on previous work, we hypothesized that training abstract words in either language would promote within-language generalization, while training in the nondominant language would promote both within- and cross-language generalization. METHODS: This case study used a single-subject A1BA2CA3 design. The participant was living with aphasia secondary to stroke and spoke both Polish and English, with Polish being his native and dominant language. Phase B consisted of abstract word training in Polish and phase C consisted of abstract word training in English. Prior to initiating therapy, in addition to a comprehensive language battery, we administered a cognitive control task to explore the relationship between cognitive control and treatment outcome. RESULTS: We found within-language generalization regardless of the trained language, replicating previous work in monolingual persons with aphasia, further supporting the utility of training abstract words. However, contrary to our second hypothesis, cross-language generalization only occurred when the stronger language was trained. CONCLUSIONS: The discussion of the results of this case study is framed within previous work and theories of bilingualism. The lack of cross-language generalization when the weaker language was trained is discussed, taking into account nonverbal cognitive control deficits. In addition to showing the efficacy of BAbSANT, these results highlight the importance of considering cognitive control as a factor influencing therapeutic outcomes in anomia treatment in bilingual PWA.

Cognitive and Linguistic Benefits of Aerobic Exercise: A State-of-the-Art Systematic Review of the Stroke Literature.

This systematic review aimed to determine how aerobic exercise affects cognition after stroke, with particular focus on aphasia and language improvement. Methodological quality was assessed with the PEDro+ scale with half of the 27 included studies rated as high quality. Data extraction focused on cognitive effects of aerobic exercise post-stroke, intervention characteristics, outcome measures, and participant characteristics. Whereas attention, memory, and executive functioning measures were common across the included studies, no study included a language-specific, performance-based measure. Seventeen studies reported positive cognitive effects, most frequently in the domains of attention, memory and executive functioning. Variability in outcome measures, intervention characteristics, and participant characteristics made it difficult to identify similarities among studies reporting positive cognitive effects of exercise or among those studies reporting null outcomes. Only three studies provided specific information about the number of individuals with aphasia included or excluded, who comprise approximately one-third of the stroke population. The review identified patent gaps in our understanding of how aerobic exercise may affect not only the cognitive domain of language post-stroke but also the broader cognitive functioning of individuals with post-stroke aphasia. Methodological limitations of the reviewed studies also warrant further examination of the direct impact of aerobic exercise on cognition post-stroke with careful attention to the selection and reporting of population, intervention, and outcomes.

Abstract Semantic Associative Network Training: A Replication and Update of an Abstract Word Retrieval Therapy Program.

Purpose We report on a study that replicates previous treatment studies using Abstract Semantic Associative Network Training (AbSANT), which was developed to help persons with aphasia improve their ability to retrieve abstract words, as well as thematically related concrete words. We hypothesized that previous results would be replicated; that is, when abstract words are trained using this protocol, improvement would be observed for both abstract and concrete words in the same context-category, but when concrete words are trained, no improvement for abstract words would be observed. We then frame the results of this study with the results of previous studies that used AbSANT to provide better evidence for the utility of this therapeutic technique. We also discuss proposed mechanisms of AbSANT. Method Four persons with aphasia completed one phase of concrete word training and one phase of abstract word training using the AbSANT protocol. Effect sizes were calculated for each word type for each phase. Effect sizes for this study are compared with the effect sizes from previous studies. Results As predicted, training abstract words resulted in both direct training and generalization effects, whereas training concrete words resulted in only direct training effects. The reported results are consistent across studies. Furthermore, when the data are compared across studies, there is a distinct pattern of the added benefit of training abstract words using AbSANT. Conclusion Treatment for word retrieval in aphasia is most often aimed at concrete words, despite the usefulness and pervasiveness of abstract words in everyday conversation. We show the utility of AbSANT as a means of improving not only abstract word retrieval but also concrete word retrieval and hope this evidence will help foster its application in clinical practice.

Hypoconnectivity of Resting-State Networks in Persons with Aphasia Compared with Healthy Age-Matched Adults.

Aphasia is a language disorder affecting more than one million people in the US. While language function has traditionally been the focus of neuroimaging research, other cognitive functions are affected in this population, which has implications not only for those specific processes but also for the interaction of language and other cognitive functions. Resting state fMRI (rs-fMRI) is a practical and informative way to explore and characterize general cognitive engagement and/or health in this population, but it is currently underutilized. The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared with 11 neurologically healthy adults (NHA) in order to gain a more comprehensive understanding of general cognitive engagement in aphasia. These preliminary results show that PWA exhibit hypoconnectivity in the semantic network and all RSNs except the visual network. Compared with NHA, PWA appear to have fewer cross- and left-hemispheric connections. However, PWA exhibit some stronger connections than NHA within the semantic network, which could indicate compensatory mechanisms. Importantly, connectivity for RSNs appear to increase with decreasing aphasia severity and decrease with increasing lesion size. This knowledge has the potential to improve aphasia therapy by furthering the understanding of lesion effects on the cognitive system as a whole, which can guide treatment target selection and promotion of favorable neural reorganization for optimal recovery of function.

Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia.

The neural mechanisms that underlie generalization of treatment-induced improvements in word finding in persons with aphasia (PWA) are currently poorly understood. This study aimed to shed light on changes in functional network connectivity underlying generalization in aphasia. To this end, we used fMRI and graph theoretic analyses to examine changes in functional connectivity after a theoretically-based word-finding treatment in which abstract words were used as training items with the goal of promoting generalization to concrete words. Ten right-handed native English-speaking PWA (7 male, 3 female) ranging in age from 47 to 75 (mean=59) participated in this study. Direct training effects coincided with increased functional connectivity for regions involved in abstract word processing. Generalization effects coincided with increased functional connectivity for regions involved in concrete word processing. Importantly, similarities between training and generalization effects were noted as were differences between participants who generalized and those who did not.