1.
Br J Gen Pract
; 46(410): 551-2, 1996 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8917880
2.
Biochem Soc Trans
; 23(1): 89S, 1995 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7538953
Assuntos
Epitopos/biossíntese , Receptores de Dopamina D2/biossíntese , Sequência de Aminoácidos , Animais , Linhagem Celular , DNA Complementar , Dados de Sequência Molecular , Peso Molecular , Reação em Cadeia da Polimerase , Receptores de Dopamina D2/isolamento & purificação , Proteínas Recombinantes/biossíntese , Sitios de Sequências Rotuladas , Espiperona/metabolismo , Spodoptera , Transfecção
3.
Brain Res
; 617(2): 349-52, 1993 Jul 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8402163
RESUMO
Rats receiving 4 mg nicotine/kg/day via implanted minipumps sustained plasma nicotine concentrations of 40 ng/ml throughout two weeks of nicotine infusion. Numbers of brain [3H]nicotine binding sites were increased by about 50% in cortex and hippocampus whereas numbers of [3H]nicotine binding sites in striatum were unaffected by nicotine treatment at either of the timepoints examined (7, 14 days). Cortical [125I] alpha-bungarotoxin and [3H]QNB binding sites were also unchanged. The regional selectivity of nicotinic receptor modulation may reflect the low dose of nicotine used and the mode of administration. The changes observed may be pertinent to the continuous administration of nicotine in man, via transdermal nicotine patches.