RESUMO
Studies in the morphology, histochemistry, and ultrastructure of the cerebellum, with special reference to the Purkinje cell dendrites, have been undertaken in eight cases of gargoylism. The results suggest that the demonstration of ovoid swellings of the Purkinje cell dendrites by the Cajal method for the cerebellum, together with certain histochemical findings, may enable a diagnosis of mucopolysaccharidosis to be made. Possible mechanisms for the formation of these swellings are briefly discussed.
Assuntos
Córtex Cerebelar/patologia , Glicolipídeos/metabolismo , Corpos de Inclusão/ultraestrutura , Deficiência Intelectual/patologia , Mucopolissacaridoses/patologia , Células de Purkinje/ultraestrutura , Retinose Pigmentar/patologia , Adolescente , Gânglios da Base/patologia , Encéfalo/patologia , Córtex Cerebral/patologia , Criança , Feminino , Histocitoquímica , Humanos , Corpos de Inclusão/metabolismo , Deficiência Intelectual/metabolismo , Masculino , Meninges/patologia , Microscopia Eletrônica , Mucopolissacaridoses/metabolismo , Tamanho do Órgão , Retinose Pigmentar/metabolismo , SíndromeAssuntos
Doenças do Recém-Nascido , Esclerose Tuberosa , Autopsia , Encéfalo/patologia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/patologia , Humanos , Recém-Nascido , Masculino , Rabdomioma/complicações , Rabdomioma/patologia , Esclerose Tuberosa/complicações , Esclerose Tuberosa/patologiaRESUMO
Meningoencephalitis proved to be due to an amoeba (Naegleria) has been diagnosed in Great Britain for the first time. The first patient (a boy of 2) survived longer than any previously recorded cases, but in spite of early diagnosis and treatment he died 15 days after the onset of meningeal symptoms.Two other children who were exposed to the same possible source of infection (a warm, muddy puddle) had similar symptoms and developed mild meningitis. A naegleria was isolated from the cerebrospinal fluid of one of them. Both recovered after treatment with amphotericin.
