Assuntos
Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/prevenção & controle , Dermatite Ocupacional/etiologia , Dermatite Ocupacional/prevenção & controle , Detergentes/efeitos adversos , Tiazóis/efeitos adversos , Adulto , Alitretinoína/uso terapêutico , Cosméticos/efeitos adversos , Dermatite Alérgica de Contato/tratamento farmacológico , Dermatite Ocupacional/tratamento farmacológico , Fármacos Dermatológicos/uso terapêutico , Dermatoses da Mão , Humanos , Masculino , Saúde Ocupacional , Pintura/efeitos adversos , Testes do Emplastro , Prurido , Recidiva , Prevenção Secundária , Esteroides/uso terapêutico , Resultado do TratamentoRESUMO
In the period from 1891 - 1910, around 2000 patients with syphilis were admitted to the Department of Dermatology, Oslo University Hospital, Rikshospitalet. The head of the department, Cæsar Boeck (1845 - 1917), believed in allowing the disease to take its natural course and withheld treatment. He made detailed notes of the diagnosis and the clinical course of the disease for all his patients. Boeck's material is unique, and forms the basis for our current knowledge about the prognosis and course of syphilis infections. In 1928, the patients were scrutinised by Boeck's successor in the Department of Dermatology, Edvin Bruusgaard (1869 - 1934), and later by Trygve Gjestland (1911 - 1993). Gjestland's doctoral thesis from 1955 has remained as «The Oslo study of untreated syphilis.¼ This article presents a medical historical background for the study. Bruusgaard's and Gjestland's research was important for the Tuskegee Study in the USA, and the Oslo study gave implicit support to this research project, which posterity has emphatically condemned as ethically unacceptable.
Assuntos
Experimentação Humana , Sífilis/história , Suspensão de Tratamento , Negro ou Afro-Americano , Dermatologia , Feminino , História do Século XIX , História do Século XX , Departamentos Hospitalares , Experimentação Humana/ética , Experimentação Humana/história , Humanos , Masculino , Mercúrio/história , Mercúrio/uso terapêutico , Noruega/epidemiologia , Penicilinas/história , Penicilinas/uso terapêutico , Sífilis/epidemiologia , Sífilis/terapia , Estados Unidos/epidemiologia , Suspensão de Tratamento/ética , Suspensão de Tratamento/históriaRESUMO
We present a case report of an auxiliary nurse who developed an adenoid cystic carcinoma in her left maxillary sinus following occupational exposure to formaldehyde in the operating theatre. Currently, the epidemiological evidence that formaldehyde can cause cancer in humans is considered to be limited. Previous case-control-studies of formaldehyde and sinonasal cancer have mainly investigated subjects who were concomitantly exposed to wood dust, a known risk factor to the development of sinonasal adenocarcinoma of intestinal type. Our case report presents a patient who has developed an adenoid cystic carcinoma following exposure to formaldehyde. We suggest that the occupational physician remains alert to formaldehyde as an occupational hazard among health care workers.
