Comorbidity-Guided Text Mining and Omics Pipeline to Identify Candidate Genes and Drugs for Alzheimer's Disease.

Alzheimer's disease (AD), a multifactorial neurodegenerative disorder, is prevalent among the elderly population. It is a complex trait with mutations in multiple genes. Although the US Food and Drug Administration (FDA) has approved a few drugs for AD treatment, a definitive cure remains elusive. Research efforts persist in seeking improved treatment options for AD. Here, a hybrid pipeline is proposed to apply text mining to identify comorbid diseases for AD and an omics approach to identify the common genes between AD and five comorbid diseases-dementia, type 2 diabetes, hypertension, Parkinson's disease, and Down syndrome. We further identified the pathways and drugs for common genes. The rationale behind this approach is rooted in the fact that elderly individuals often receive multiple medications for various comorbid diseases, and an insight into the genes that are common to comorbid diseases may enhance treatment strategies. We identified seven common genes-PSEN1, PSEN2, MAPT, APP, APOE, NOTCH, and HFE-for AD and five comorbid diseases. We investigated the drugs interacting with these common genes using LINCS gene-drug perturbation. Our analysis unveiled several promising candidates, including MG-132 and Masitinib, which exhibit potential efficacy for both AD and its comorbid diseases. The pipeline can be extended to other diseases.

Urgency for sustainable development in coastal urban areas with reference to weather pattern, land use, and water quality.

Water pollution is one of the most critical problems affecting mankind. Weather pattern and land use of catchment area have significant role in quality of water bodies. Due to climate change, there is frequent variation in weather pattern all over the world. There is also rapid change in land use due to increase in population and urbanization. The study was carried out to analyze the effect of change in weather pattern during the monsoon periods of 2008 and 2012 on water quality of a tropical coastal lake system. The nature and extent of variation in different water quality parameters namely electrical conductivity (EC), magnesium (Mg), sodium (Na), chloride (Cl), sulphate (SO4), turbidity, Secchi disk depth, biochemical oxygen demand (BOD), phosphate (PO4), calcium (Ca), and water temperature as well as the effect of various land use activities in the lake basin on water quality have also been studied. There is significant reduction in precipitation, EC, Mg, Na, Cl, SO4, turbidity, and Secchi disk depths whereas a significant rise in the BOD, PO4, Ca, and water temperature were observed in 2012. This significant reduction in electrical conductivity during 2012 revealed that because of less precipitation, the lake was separated from the sea by the sandbar during most of the monsoon period and thereby interrupted the natural flushing process. This caused the accumulation of organic matter including phosphate and thereby resulting reduction in clarity and chlorophyll-a (algae) in the lake. The unsustainable development activities of Thiruvanathapuram city are mainly responsible for the degradation of water bodies. The lack of maintenance and augmentation activities namely replacement of old pipes and periodical cleaning of pipe lines of the old sewer system in the city results in the bypass of sewage into water bodies. Because of the existence of the old sewerage system, no effort has been taken by the individual establishment/house of the city to provide their own treatment system for sewage and sullage and the untreated wastes are discharged into these old sewer pipes and ultimately the wastes reach the water bodies. In this context, decentralized treatment of sewage, sullage, and garbage by individual houses/establishments/hotels/hospitals is a better option for the developing countries. With the rapid developmental activities, and due to the variation of precipitation due to climate change, it is highly essential to provide proper waste treatment/augmentation facilities in urban lake system because a slight variation in the weather pattern can result in serious implications in the already polluted water bodies.