A fuzzy ANP-DEMATEL model on faulty behavior risks: implications for improving safety in the workplace.

The occurrence of occupational accidents and injuries has always been a major concern for industrial management. Such undesirable incidences are higher in developing countries, especially in India, than in developed countries. This research aims to identify, analyze and evaluate the faulty behavior risks (FBRs) that trigger occupational accidents and injuries. Using a data triangulation strategy, this study identified 19 FBR factors under five categories. An integrated approach comprising the fuzzy analytic network process (ANP) and the decision-making trial and evaluation laboratory (DEMATEL) method is proposed for assessing these FBRs. The five most prominent critical risk factors are the absence of continuous monitoring, defective equipment and maintenance, cognitive bias, proper signage and adverse ambient working conditions. The study postulates some implications for industrial management to mitigate occupational accidents and injuries based on the outcomes.

Modeling a pH-sensitive Zein-co-acrylic acid hybrid hydrogels loaded 5-fluorouracil and rutin for enhanced anticancer efficacy by oral delivery.

The combination of natural and synthetic polymeric materials grafted hydrogels offer great potential as oral therapeutic systems because of its intrinsic biocompatibility, biodegradability, protect labile drugs from metabolism and controlled release properties. Hence, in the present study, we aimed to prepare and optimize oral delivered pH-responsive Zein-co-acrylic acid hydrogels incorporated with 5-fluorouracil (5-Fu) and rutin (Ru) for effective anticancer activity with less toxicity. In this study, graft polymerization technique is adopted to formulate hydrogels with various ratios of Zein, acrylic acid, N, N-methylene bisacrylamide, and ammonium persulphate as an initiator. The optimized formulation was identified based on the cross-linking, chemical interactions, intrinsic viscosity (η), dynamic swelling (Q) at pH 1.2, diffusion coefficient (D), sol-gel fraction (%), and porosity (%). The selected optimized formulation has shown significant improvement in drugs loading and encapsulation efficiency, releasing at pH 1.2 and pH 7.4. Drug release kinetics studies confirmed the controlled release properties of hydrogels. Hydrogels were porous and the drug loading of 5-Fu and Ru was found to be 12.13% and 10.86%, respectively, whereas encapsulation efficiency of 5-Fu and Ru was 89.35% and 81.47%, respectively. Furthermore, form the in vitro cytotoxic screening, it was found that 52.5 µg mL-1 5-Fu and Ru-loaded hydrogel impacted 50% of cell death at 24 h, there by significantly arresting the proliferation of MDA-MB-231 and MCF-7 breast cancer cell lines. Altogether, the optimized pH-responsive hydrogels make them favorable carrier for anticancer drugs for oral delivery.