Assuntos
Epididimo , Granuloma/patologia , Orquite/patologia , Tuberculose dos Genitais Masculinos/diagnóstico , Tuberculose Renal/diagnóstico , Adulto , Humanos , Masculino , Necrose , Radiografia , Tuberculose dos Genitais Masculinos/diagnóstico por imagem , Tuberculose dos Genitais Masculinos/patologia , Tuberculose Renal/diagnóstico por imagem , Tuberculose Renal/patologiaRESUMO
1. The effects of haloperidol on the responses of the isolated rat vasa deferentia to catecholamines and ACh were studied. 2. Haloperidol produced a competitive antagonism to responses elicited by NA and DA in the vas deferens. 3. The M1 and M2 muscarinic responses to ACh of the vas deferens were potentiated by this neuroleptic. 4. The AChE activity of the vas deferens was significantly depressed by pretreatment with haloperidol. 5. The ability of haloperidol to lower AChE activity was compared with that of neostigmine and it may be due to a similar molecular mechanism. 6. The present results suggest that haloperidol has anti-AChE properties that may be responsible for the potentiation of the responses to ACh. 7. The study indicates that haloperidol has a wider range of pharmacological actions than previously reported.
Assuntos
Haloperidol/farmacologia , Músculo Liso/metabolismo , Neurotransmissores/metabolismo , Acetilcolinesterase/metabolismo , Animais , Catecolaminas/metabolismo , Técnicas In Vitro , Masculino , Contração Muscular/efeitos dos fármacos , Músculo Liso/efeitos dos fármacos , Músculo Liso/enzimologia , Neostigmina/farmacologia , Ratos , Ratos Endogâmicos , Ducto Deferente/efeitos dos fármacos , Ducto Deferente/enzimologia , Ducto Deferente/metabolismoRESUMO
Changes in the activity of acetylcholinesterase (AChE) of the isolated vas deferens from normal, castrated, morphine and ethanol-tolerant rats were studied. Three days after the termination of treatment with morphine and on the last day of treatment with ethanol, a significant inhibition of the activity of AChE was detected. This reduction in the enzymatic activity persisted in morphine-tolerant rats for 15 days, but not for 30 days, at which time the levels of AChE were determined to be normal. However, in ethanol-tolerant rats, there were no significant changes found at days 15 or 30. The activity of AChE was decreased significantly in castrated rats, but this effect was reversed by treatment with testosterone. During withdrawal from morphine or ethanol, the levels of AChE were significantly increased. The results indicate that morphine and ethanol may be inducing changes in the feedback mechanism which regulates the levels of AChE at post-synaptic sites, and these changes could play an important role in the development of tolerance to morphine and to ethanol.
Assuntos
Acetilcolinesterase/metabolismo , Músculo Liso/enzimologia , Orquiectomia , Animais , Tolerância a Medicamentos , Técnicas In Vitro , Masculino , Morfina/farmacologia , Músculo Liso/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Síndrome de Abstinência a Substâncias/fisiopatologia , Testosterona/farmacologiaRESUMO
The study was undertaken to obtain some information about the development of the autonomic receptors and the AChE activity in the rat vas deferens. The results suggest that the adrenoceptors were fully developed at birth. The M1-ACh receptors were developed before the M2-ACh receptors. The AChE activity developed before the ACh muscarinic receptors of the rat vas deferens.
