Resecciones hepáticas laparoscópicas: ¿qué hemos aprendido luego de más de 20 años de experiencia? / Laparoscopic liver resections: What have we learned after more than 20 years of experience?

Introducción: El objetivo de este estudio es describir nuestra experiencia en los últimos 8años de resecciones hepáticas laparoscópicas (RHL) por tumores benignos y malignos, para evaluar indicaciones y resultados, y comparar los resultados con nuestra experiencia previa y con otros centros de referencia a nivel mundial. Métodos: A partir de una base de datos prospectiva de la Unidad de Cirugía Hepatopancreatobiliar y Trasplante Hepático del Hospital Italiano de Buenos Aires se analizaron de forma retrospectiva los pacientes que fueron sometidos a RHL entre septiembre de 2014 y junio de 2022 (períodoB) y se compararon los resultados con nuestra propia experiencia de RHL realizadas entre los años 2000 y 2014, publicada previamente (períodoA). Resultados: La indicación quirúrgica más frecuente fue por metástasis de cáncer colorrectal (26,4%). El 15,7% de las resecciones fueron hepatectomías mayores y el procedimiento más frecuentemente realizado fueron hepatectomías típicas y atípicas (58,4%), seguido por la hepatectomía lateral izquierda (20,3%). La tasa de complicaciones mayores fue del 10,1%. La mortalidad en los primeros 90días postoperatorios fue del 1%. La mediana de estancia postoperatoria fue de 4 (IQR: 3-6) días. La sobrevida global al año, a los 3 y a los 5años fue del 94%, del 84% y del 70%, respectivamente, con una media de seguimiento de 22,9meses. Conclusiones: Las resecciones hepáticas por vía laparoscópica en manos de cirujanos entrenados continúan creciendo de manera segura, y hemos visto un aumento en la indicación de RHL para patologías malignas y resecciones mayores, tendencia que acompaña al resto de los grandes centros del mundo y se ha convertido en el método de elección para el tratamiento quirúrgico de la mayoría de los tumores hepáticos. (AU)

Introduction: The aim of this study is to describe our experience in the last 8years of laparoscopic liver resections (LLR) for benign and malignant tumors, to evaluate indications and results, and to compare the results with our previous experience and with other reference centers worldwide. Methods: Based on a prospective database of the Hepatopancreatobiliary Surgery and Liver Transplantation Unit of the Hospital Italiano de Buenos Aires, patients who underwent LLR between September 2014 and June 2022 were retrospectively analyzed (periodB) and where compared to our own experience from 2000-2014 previously published (periodA). Results: Colorectal liver metastasis was the main indication for surgery (26.4%). Major hepatectomies accounted for 15.7% of resections and the most frequently performed procedure was typical and atypical hepatectomies (58.4%) followed by left lateral hepatectomy (20.3%). The total postoperative major complications rate was 10.1% and the 90-day postoperative mortality was 1%. The median postoperative stay was four (IQR: 3-6) days. The overall survival rate estimated at 1, 3 and 5 years was 94%, 84% and 70%, respectively, with a median follow-up of 22.9months. Conclusions: LLRs in the hands of trained surgeons continue to grow safely, and we have seen an increase in the indication of LLR for malignant pathologies and major resections, a trend that follows the rest of the major centers in the world and has become the method of choice for surgical treatment of most liver tumors. (AU)

Síndrome de hipoglucemia por hiperinsulinismo endógeno: tratamiento quirúrgico / Endogenous hyperinsulinemic hypoglycemia syndrome: Surgical treatment

INTRODUCCIÓN: El síndrome hipoglucémico por hiperinsulinismo endógeno (SHHE) puede estar originado por un insulinoma o, menos frecuentemente, por la nesidioblastosis en niños, conocida en la población adulta con el nombre de síndrome hipoglucémico pancreático no insulinoma (SHPNI). El objetivo de este trabajo es mostrar la estrategia para el tratamiento quirúrgico del SHHE. MATERIAL Y MÉTODO: Se incluyó a un total de 19 pacientes con diagnóstico final de insulinoma o SHPNI que fueron tratados quirúrgicamente desde enero del 2007 hasta junio del 2012. Se describió la forma de presentación clínica y estudios preoperatorios. Se hizo hincapié en la técnica quirúrgica, las complicaciones y el seguimiento a largo plazo de los pacientes. RESULTADOS: Todos los pacientes en estudio tuvieron un test de ayuno positivo. Las lesiones que originaron el SHHE pudieron ser localizadas preoperatoriamente en el 89,4% de los casos. La cirugía más frecuente fue la pancreatectomía distal con preservación de bazo (9 casos). Tres pacientes con diagnóstico de insulinoma se presentaron con metástasis sincrónicas, que fueron tratadas con cirugía simultánea. No tuvimos mortalidad perioperatoria y la morbilidad fue del 52,6%. El análisis histológico reveló que 13 pacientes (68,4%) presentaban insulinoma benigno, 3 insulinoma maligno con metástasis hepáticas y 3 con diagnóstico final de SHPNI. La mediana de seguimiento fue de 20 meses. Todos los pacientes con diagnóstico de insulinoma benigno o SHPNI resolvieron el síndrome de SHHE. CONCLUSIÓN: El tratamiento quirúrgico del SHHE logra excelentes resultados a largo plazo en el control de los síntomas de hipoglucemia

BACKGROUND: The endogenous hyperinsulinemic hypoglicemia syndrome (EHHS) can be caused by an insulinoma, or less frequently, by nesidioblastosis in the pediatric population, also known as non insulinoma pancreatic hypoglycemic syndrome (NIPHS) in adults. The aim of this paper is to show the strategy for the surgical treatment of EHHS. MATERIAL AND METHODS: A total of 19 patients with a final diagnosis of insulinoma or NIPHS who were treated surgically from January 2007 until June 2012 were included. We describe the clinical presentation and preoperative work-up. Emphasis is placed on the surgical technique, complications and long-term follow-up. RESULTS: All patients had a positive fasting plasma glucose test. Preoperative localization of the lesions was possible in 89.4% of cases. The most frequent surgery was distal pancreatectomy with spleen preservation (9 cases). Three patients with insulinoma presented with synchronous metastases, which were treated with simultaneous surgery. There was no perioperative mortality and morbidity was 52.6%. Histological analysis revealed that 13 patients (68.4%) had benign insulinoma, 3 malignant insulinoma with liver metastases and 3 with a final diagnosis of SHPNI. Median follow-up was 20 months. All patients diagnosed with benign insulinoma or NIPHS had symptom resolution. CONCLUSION: The surgical treatment of EHHS achieves excellent long-term results in the control of hypoglucemic symptoms

Enucleación laparoscópica de una neoplasia intraductal papilar mucinosa de ramos periféricos localizada en la cabeza del páncreas. Una nueva alternativa / Laparoscopic enucleation of a peripheral branch intraductal papillary mucinous neoplasm situated in the pancreatic head. A new alternative

No disponible

Groove pancreatitis vs groove pancreatic adenocarcinoma. Report of two cases and review of the literature.

Groove pancreatitis (GP) is a rare form of segmental chronic pancreatitis affecting the groove area (anatomic space between the head of the pancreas, the duodenum and the common bile duct). Its clinical and radiological presentation may be similar to groove pancreatic adenocarcinoma (GPA). Nevertheless, treatment and prognosis are totally different. We report two cases of both GP and GPA and review the relevant aspects that may help to clarify the differential diagnosis between these two rare entities. The first patient is a 57-year-old man with a history of chronic alcohol consumption who presented with persistent abdominal pain. The CT-scan findings suggested GP. Due to the persistence of symptoms despite medical treatment, a pancreaticoduodenectomy was performed. Pathologic evaluation confirmed the diagnosis of GP. The second patient is a 72-year-old male who presented with cholestasis and weight loss. The tumor marker CA 19-9 was increased The CT-scan findings were consistent with duodenal dystrophy. In order to rule out malignancy a pancreaticoduodenectomy was performed. Pathologic evaluation revealed a pancreatic head adenocarcinoma (T3-N1-M0). GP is a rare entity that should be suspected in patients with a history of heavy alcohol consumption who complain of chronic abdominal pain and weight loss. Patients without a clear diagnosis even after a through imaging work-up, or those in whom symptoms are persistent in spite of medical therapy, should undergo surgical exploration.

Manejo actual del cáncer de páncreas / Current management of pancreatic cancer

El cáncer de páncreas (CP) representa la cuarta causa de muerte por cáncer en países occidentales. En las últimas décadas se han obtenido múlti- ples avances respecto del entendimiento de la biología tumoral, así como en el diagnóstico, tratamiento y paliación del CP; esto demuestra que el abordaje multidisciplinario de dicha patología es esencial. La cirugía representa la mejor opción terapéutica para aquellos pacientes con enferme- dad localizada. Lamentablemente, más del 85% de ellos son diagnosticados cuando el CP se encuentra en estadios avanzados de la enfermedad. El tratamiento adyuvante, especialmente la quimioterapia, ha mejorado significativamente la supervivencia de los pacientes con CP.

Manejo actual del cáncer de páncreas / Current management of pancreatic cancer

El cáncer de páncreas (CP) representa la cuarta causa de muerte por cáncer en países occidentales. En las últimas décadas se han obtenido múlti- ples avances respecto del entendimiento de la biología tumoral, así como en el diagnóstico, tratamiento y paliación del CP; esto demuestra que el abordaje multidisciplinario de dicha patología es esencial. La cirugía representa la mejor opción terapéutica para aquellos pacientes con enferme- dad localizada. Lamentablemente, más del 85% de ellos son diagnosticados cuando el CP se encuentra en estadios avanzados de la enfermedad. El tratamiento adyuvante, especialmente la quimioterapia, ha mejorado significativamente la supervivencia de los pacientes con CP.(AU)

Groove pancreatitis vs groove pancreatic adenocarcinoma. Report of two cases and review of the literature / Groove pancreatitis vs groove pancreatic adenocarcinoma. Report of two cases and review of the literature.

Groove pancreatitis (GP) is a rare form of segmental chronic pancreatitis affecting the groove area (anatomic space between the head of the pancreas, the duodenum and the common bile duct). Its clinical and radiological presentation may be similar to groove pancreatic adenocarcinoma (GPA). Nevertheless, treatment and prognosis are totally different. We report two cases of both GP and GPA and review the relevant aspects that may help to clarify the differential diagnosis between these two rare entities. The first patient is a 57-year-old man with a history of chronic alcohol consumption who presented with persistent abdominal pain. The CT-scan findings suggested GP. Due to the persistence of symptoms despite medical treatment, a pancreaticoduodenectomy was performed. Pathologic evaluation confirmed the diagnosis of GP. The second patient is a 72-year-old male who presented with cholestasis and weight loss. The tumor marker CA 19-9 was increased The CT-scan findings were consistent with duodenal dystrophy. In order to rule out malignancy a pancreaticoduodenectomy was performed. Pathologic evaluation revealed a pancreatic head adenocarcinoma (T3-N1-M0). GP is a rare entity that should be suspected in patients with a history of heavy alcohol consumption who complain of chronic abdominal pain and weight loss. Patients without a clear diagnosis even after a through imaging work-up, or those in whom symptoms are persistent in spite of medical therapy, should undergo surgical exploration.

Groove pancreatitis vs groove pancreatic adenocarcinoma. Report of two cases and review of the literature. / Groove pancreatitis vs groove pancreatic adenocarcinoma. Report of two cases and review of the literature.

Groove pancreatitis (GP) is a rare form of segmental chronic pancreatitis affecting the groove area (anatomic space between the head of the pancreas, the duodenum and the common bile duct). Its clinical and radiological presentation may be similar to groove pancreatic adenocarcinoma (GPA). Nevertheless, treatment and prognosis are totally different. We report two cases of both GP and GPA and review the relevant aspects that may help to clarify the differential diagnosis between these two rare entities. The first patient is a 57-year-old man with a history of chronic alcohol consumption who presented with persistent abdominal pain. The CT-scan findings suggested GP. Due to the persistence of symptoms despite medical treatment, a pancreaticoduodenectomy was performed. Pathologic evaluation confirmed the diagnosis of GP. The second patient is a 72-year-old male who presented with cholestasis and weight loss. The tumor marker CA 19-9 was increased The CT-scan findings were consistent with duodenal dystrophy. In order to rule out malignancy a pancreaticoduodenectomy was performed. Pathologic evaluation revealed a pancreatic head adenocarcinoma (T3-N1-M0). GP is a rare entity that should be suspected in patients with a history of heavy alcohol consumption who complain of chronic abdominal pain and weight loss. Patients without a clear diagnosis even after a through imaging work-up, or those in whom symptoms are persistent in spite of medical therapy, should undergo surgical exploration.