Qualidade de vida em transplantes renais / Quality of life in kidney transplant / Calidad de vida en trasplante de riñón

A doença renal crônica afeta milhares de pessoas e é atualmente um problema de saúde pública. O transplante renal é uma das formas de tratamento utilizada com objetivo de melhorar a qualidade de vida desses indivíduos. Este estudo buscou traçar o perfil sociodemográfico, compreender o significado do transplante renal e o seu impacto na qualidade de vida. Participaram 12 pacientes transplantados, em acompanhamento ambulatorial no Hospital público localizado em Recife. Utilizou-se questionário sociodemográfico e roteiro de entrevista semiestruturado. A maioria eram adultos jovens, casados, possuíam ensino médio completo, católicos e com até cinco anos de hemodiálise. As entrevistas foram categorizadas em: impacto do diagnóstico, limites da hemodiálise, restrições alimentares e a liberdade do transplante. Por meio desse estudo, foi possível observar que o transplante favoreceu a melhoria da qualidade de vida dos pacientes, além disso, pode nortear os profissionais de saúde e os pacientes que vislumbram a realização desse procedimento. (AU)

Chronic kidney disease affects thousands of people and is currently a public health problem. Kidney transplantation is one of the forms of treatment used in order to improve the quality of life of these individuals. This study sought to trace the socio-demographic profile and to understand the significance of kidney transplantation and its impact on quality of life. Participants included 12 transplant patients under outpatient treatment at the public Hospital located in Recife. We used a socio-demographic questionnaire and a semi-structured interview. Most patients were young adults, married, had completed/incomplete secondary education, were Catholic and had been on hemodialysis for up to 5 years. The interviews were categorized as: impact of the diagnosis, hemodialysis limits and restrictions and the freedom of transplantation. Through this study it was possible to observe that the transplant has helped to improve the patients' quality of life and it can also guide healthcare professionals and patients who envisage performing this procedure. (AU)

La enfermedad renal crónica afecta a muchas personas y actualmente se ha convertido en un problema de salud pública. El trasplante renal es una de las formas de tratamiento que busca mejorar la calidad de vida de las mismas. Este estudio buscó trazar un perfil sociodemográfico, y comprender el significado del trasplante renal y su impacto en la calidad de vida. Participaron 12 pacientes trasplantados con seguimiento ambulatorio en el Hospital público ubicado en Recife. Se utilizó un cuestionario sociodemográfico y una entrevista semiestructurada. La mayoría eran jóvenes adultos, con Enseñanza Secundaria completa, casados, católicos y con hasta 5 años de hemodiálisis. Las entrevistas se clasificaron en: impacto de diagnóstico, límites de hemodiálisis, restricciones alimenticias y libertad de trasplante. A través de este estudio se observó que el trasplante ha ayudado a mejorar la calidad de vida de los pacientes y además puede orientar a profesionales de la salud y a los pacientes que preeven la realización de ese procedimiento. (AU)

Catechin and epicatechin reduce mitochondrial dysfunction and oxidative stress induced by amiodarone in human lung fibroblasts.

BACKGROUND: Amiodarone (AMD) and its metabolite N-desethylamiodarone can cause some adverse effects, which include pulmonary toxicity. Some studies suggest that mitochondrial dysfunction and oxidative stress may play a role in these adverse effects. Catechin and epicatechin are recognized as important phenolic compounds with the ability to decrease oxidative stress. Therefore, the aim of this study was to evaluate the potential of catechin and epicatechin to modulate mitochondrial dysfunction and oxidative damage caused by AMD in human lung fibroblast cells (MRC-5). METHODS: Mitochondrial dysfunction was assessed through the activity of mitochondrial complex I and ATP biosynthesis. Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Superoxide dismutase and catalase activity were measured spectrophotometrically at 480 and 240 nm, respectively. Lipid and protein oxidative levels were determined by thiobarbituric reactive substances and protein carbonyl assays, respectively. Nitric oxide (NO) levels were evaluated using the Griess reaction method. RESULTS: AMD was able to inhibit the activity of mitochondrial complex I and ATP biosynthesis in MRC-5 cells. Lipid and protein oxidative markers increased along with cell death, while superoxide dismutase and catalase activities and NO production decreased with AMD treatment. Both catechin and epicatechin circumvented mitochondrial dysfunction, thereby restoring the activity of mitochondrial complex I and ATP biosynthesis. Furthermore, the phenolic compounds were able to restore the imbalance in superoxide dismutase and catalase activities as well as the decrease in NO levels induced by AMD. Protein and lipid oxidative damage and cell death were reduced by catechin and epicatechin in AMD-treated cells. CONCLUSIONS: Catechin and epicatechin reduced mitochondrial dysfunction and oxidative stress caused by AMD in MRC-5 cells.

A Experiência da primeira sessão de hemodiálise: uma investigação fenomenológica / The experience of the first session of hemodialysis: a phenomenological investigation / La experiéncia de la primera sesión de hemodiálisis: una investigación

O presente estudo faz parte de uma pesquisa que procurou investigar a experiência da primeira sessão de hemodiálise para o paciente renal crônico a luz da fenomenologia. O objetivo deste estudo é compreender o significado de se submeter à Hemodiálise de urgência a partir da experiência do Doente Renal Crônico. Atrelado a este, intenciona-se descrever o significado de submeter-se a hemodiálise, investigar a compreensão do Doente Renal Crônico e pesquisar sua expectativa quanto aos cuidados relacionados à saúde e seus hábitos de vida. Este estudo baseia-se na proposta de Estudo de Caso que permite uma visão em maior profundidade acerca dos fenômenos humanos. Para análise do material, foi utilizado o Método Fenomenológico de Investigação em Psicologia de Amedeo Giorgi de metodologia qualitativa, que estuda o sentido da experiência humana nas suas mais variadas relações com o mundo. Foi escolhido para colaborar com o estudo um participante em sua primeira sessão de hemodiálise acompanhado no Hospital das Clínicas de Pernambuco. Este estudo aponta que a experiência da primeira sessão de hemodiálise é algo singular para os sujeitos e que apesar do avanço tecnológico e as abordagens médicas, aceitar tal condição depende do paciente e a sua forma de relacionar-se com o adoecimento.

This study is part of a search that sought to investigate the experience of the first hemodialysis session for the chronic renal patient in the light of phenomenology. The present study aims to understand the meaning of submitting to the Hemodialysis urgency from the chronic renal patient experience. In addition to this, it intends to describe the meaning of undergoing hemodialysis, investigate the Chronic Renal patient understanding and search your expectations for the care related to his or her health and lifestyle habits. This study is based on a case study proposal that allows a vision of greater depth about human phenomena. For material analysis it was used the phenomenological Research's Method in Psychology of Amedeo Giorgi in qualitative methodology, which studies the sense of human experience in its various relations with the world. It was chosen to collaborate with this study a participant in its first hemodialysis session that was accompanied at Hospital das Clínicas de Pernambuco. This study points to a singular experience for the subjects in the first session of hemodialysis despite the technological advancement and the medical approaches, accept this condition depends on the patient and its way of relating with the illness.

Este estudio es parte de una investigación científica que intentó investigar la experiencia de la primera sesión de hemodiálisis para pacientes renales crónicos la luz de la fenomenología. El objetivo de este estudio es comprender el significado que se someten a hemodiálisis de emergencia de la experiencia del enfermo renal crónica. Junto a esto, se tiene la intención de describir el significado de hemodiálisis, investigar la comprensión del enfermo renal crónica y buscar sus expectativas para la atención relacionada con los hábitos de salud y estilo de vida. Este estudio se basa en la propuesta de estudio de caso que permite una visión más a fondo acerca de los fenómenos humanos. Para el análisis del material, se utilizó el método de investigación fenomenológica en Psicologia de Amedeo Giorgi de la metodología cualitativa, que estudia el significado de la experiencia humana en sus múltiples relaciones con el mundo. Fue elegido para participar en el estudio de un participante en su primera sesión de hemodiálisis en el Hospital de Clínicas de Pernambuco. Este estudio muestra que la experiencia de la primera sesión de hemodiálisis es algo único para las personas e el tema ya pesar de los avances tecnológicos y los enfoques médicos, aceptar estas condiciones depende del paciente y la forma en que se relaciona con la enfermedad.

Data on cell viability of human lung fibroblasts treated with polyphenols-rich extract from Plinia trunciflora (O. Berg) Kausel).

Jaboticaba (Plinia trunciflora (O. Berg) Kausel) is a Brazilian native berry, which presents high levels of polyphenols. Here we provide data related to the effects of the polyphenols-rich extract from jaboticaba on the cell viability, mitochondrial complex I (nicotinamide adenine dinucleotide/CoQ oxidoreductase) activity and ATP biosynthesis of human lung fibroblast cells (MRC-5) treated with amiodarone. The data presented in this article demonstrate that the polyphenols-rich extract from jaboticaba was able to reduce cell death as well as the decrease in complex I activity and ATP biosynthesis caused by amiodarone in MRC-5 cells.