1.
Biomed Pharmacother
; 60(3): 121-6, 2006 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16545938
RESUMO
In the scope of a research program aiming to perform the synthesis and pharmacological evaluation of novel possible antitumour prototype compounds, we report in this paper the synthesis of new peptidyl derivatives from 4-thiazolidone nucleus. The synthesis reactions have been performed based in peptide synthesis as strategies. The characterisation of this new class of compounds was performed with IR and (1)H-NMR spectroscopy. In vivo, antitumour activity tests showed that some of these compounds were able to inhibit significantly sarcoma S-180 tumour growth in mice, revealing itself as a new potential class of drugs in cancer chemotherapy.