Research nurses contributions to research practice: an oncology nursing experience in Brazil

Background: The creation and evolution of research nurse, connected with some specialty, brings a new path to be covered and structured inside nursering. The position of Researcher Nurse was initially created decentralized only one Department. In past the years and after the role of work was being consolidating. This paper describes the creations and evolution of Research Nurses in the scene an Oncology Research Practice at a Cancer Center. Methods: Behind of a timeline description the information that in 10 years give us the number of participant departments increased, with an increase of the scientific production, besides the construction of the position of Research Nurses. Results: Throughout these years, integration and interdepartmental action were developed, with a role and seat in Biobanco, Ethics Committee in Research, Operative Systems of medical Informatics, as well as participation in multicentric, institutional projects within the Brazilian and world Oncology. Conclusions: The role of Research Nurses being

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation

Kyotorphin (KTP) is an endogenous peptide with analgesic properties when administered into the central nervous system (CNS). Its amidated form (L-Tyr-L-Arg-NH2; KTP-NH2) has improved analgesic efficacy after systemic administration, suggesting blood-brain barrier (BBB) crossing. KTP-NH2 also has anti-inflammatory action impacting on microcirculation. In this work, selected derivatives of KTP-NH2 were synthesized to improve lipophilicity and resistance to enzymatic degradation while introducing only minor changes in the chemical structure: N-terminal methylation and/or use of D amino acid residues. Intravital microscopy data show that KTP-NH2 having a D-Tyr residue, KTP-NH2-DL, efficiently decreases the number of leukocyte rolling in a murine model of inflammation induced by bacterial lipopolysaccharide (LPS): down to 46% after 30 min with 96 mu M KTP-NH2-DL. The same molecule has lower ability to permeate membranes (relative permeability of 0.38) and no significant activity in a behavioral test which evaluates thermal nociception (hot-plate test). On the contrary, methylated isomers at 96 mu M increase leukocyte rolling up to nearly 5-fold after 30 min, suggesting a proinflammatory activity. They have maximal ability to permeate membranes (relative permeability of 0.8) and induce long-lasting antinociception

La violencia contra la mujer en el ámbito familiar: estudio teórico sobre la cuestión de género / Violence against women in the family: theoretical study on the question of gender

Este es un estudio teórico que tiene el objetivo de discutir las cuestiones de género incluidas en la violencia practicada contra las mujeres en el ámbito familiar. La discusión se basa en autores que abordan la temática violencia contra la mujer y su relación con las cuestiones de género, apoyada en Joan Scott y reflexionando sobre el trabajo del (la) enfermero (a), en lo que se refiere al cuidado de las mujeres en situaciones de violencia. Las cuestiones examinadas en este ensayo pueden ayudar a la reflexión de los profesionales sobre su práctica en la búsqueda del enfrentamiento de la violencia para prevenir que el ciclo se reproduzca en la familia (AU)

This is a theoretical study that aims to discuss the gender issues involved in violence against women within the family. The discussion is grounded in authors who address the issue of violence against women and its relation to gender issues, supported by Joan Scott and reflecting on the work of a nurse in relation to the care of women in situations of violence. The issues examined in this essay may help to reflect on the practice of professionals searching to confront violence in order to prevent the cycle being reproduced within the family (AU)