ΔNp73 status in peritoneal and ovarian dissemination of appendicular adenocarcinoids (goblet cells).

INTRODUCTION: Goblet cell carcinoma (GCC) is an appendicular neoplasia representing less than 5% of all appendicular tumors, found in 0.3-0.9% of the appendectomies, 35-58% of all appendicular neoplasms, and less than 14% of malign appendix tumors. The most frequent clinical presentation is abdominal pain associated with a picture of acute appendicitis. MATERIALS AND METHODS: We present 3 clinical cases of appendix GCC, 2 subjected to cytoreductory surgery plus intraperitoneal hyperthermic chemotherapy and a third, who is currently receiving neoadjuvant treatment with a good response to chemotherapy and who will be offered the same treatment as the first two patients. Given the unpredictable behavior of these tumors, the use of molecular markers could help us to predict their behavior and prognosis. In this context, the TP73 gene would make an interesting putative marker. ∆Np73 has been described as overexpressed in a great variety of tumor types including colon cancer and this up-regulation is associated with a poor prognosis. To evidence its role in this malignancy, we evaluate here the status of ∆Np73 in the primary tumor and normal counterpart tissues, in the metastatic implants and in healthy areas of the peritoneum from the appendicular GCC patients. In addition, we checked the expression levels of this p73 variant in the tumor and normal tissue of 26 patients with colon cancer. RESULTS: Remarkably, 2 patients showed significant ∆Np73 down-regulation in both the primary tumor and the implants. Case 1 presented a fourfold decrease of levels in the primary tumor and 20-fold decrease in the implants. Case 2 showed a seven- and fourfold down-regulation in the primary tumor and implants, respectively. However, Case 3 showed an up-regulation of 53- and threefold in the primary tumor and implants, respectively. CONCLUSION: Goblet cell carcinoma of the appendix is very rate. It tends to seed throughout the peritoneum, making aggressive surgical cytoreduction and chemotherapy viable treatment options. Investigation into the molecular basis of these tumors may improve the diagnosis, prognosis and therapeutic decisions regarding these patients. ∆Np73 seems a good candidate for further analysis in longer series.

Can nonalcoholic beer, silicon and hops reduce the brain damage and behavioral changes induced by aluminum nitrate in young male Wistar rats?

Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acetylcholinesterase inhibitory activity of non-alcoholic beer (NABeer), silicon or hops, as well as their effect on animal behavior (e.g. curiosity, immobilization, rearing, grooming, swimming) and brain antioxidant enzyme (activity and gene expression) and anti-inflammatory status in aluminum nitrate intoxicated rats. Male Wistar rats were divided into five groups: 1) Control, 2) Aluminum nitrate (450 µg/kg/day), 3) Aluminum nitrate plus NABeer, 4) Aluminum nitrate plus hops, and 5) Aluminum nitrate plus silicon. Hops showed the highest in vitro antioxidant capacity and silicon the highest anticholinesterase activity. In the Aluminum group the brain aluminum/silicon ratio increased with impairment of brain antioxidant and inflammatory statuses. NABeer, silicon and hops block the negative effect on the in vivo antioxidant and inflammatory statuses induced by Aluminum nitrate and improve swimming and rearing behavioral tests. The various positive results suggest that NABeer is useful as a functional multi-target drink in the prevention of some neurodegenerative events caused by aluminum intoxication. More studies are required to conclude present results.

Trauma psíquico y psicosis. Implicaciones en la etiopatogenia, clínica, pronóstico y tratamiento / No disponible

El trauma infantil se ha asociado con enfermedadesmentales en la edad adulta, como trastornos de ansiedad,depresión, trastornos de personalidad, trastorno porestrés postraumático (TEPT), trastornos alimentarios ydependencia a drogas.Hay un interés creciente en el estudio de los factoresambientales en el desarrollo de esquizofrenia y trastornobipolar. Sin embargo no es hasta el 2004 cuandocomiezan a aparecer estudios con alta rigidez metodológicaen los cuales se analiza la relación entre trauma ypsicosis.Estudios previos ya habían detectado que los pacientescon comorbilidad entre trastorno mental grave(TMG) y TEPT, tienen un curso clinico y una peor evolución,más trastornos por abuso de alcohol y otras sustancias,más hospitalizaciones psiquiátricas, más tentativassuicidas y una peor reinseción laboral.Respecto al tratamiento los pacientes con comorbilidadTMG y TEPT existen pocos estudios. Se proponeincluir de forma rutinaria en la anamnesis los antecedentesde sucesos traumáticos(AU)

In many reports, childhood trauma (physic, psychologicaland sexual abuse), has been associated withadulthood’s mental diseases like anxiety disorders,depression, personality disorders, alcohol and otherdrugs abuse, stress posttraumatic disorder (SPTD) andeating disorders.Increassing interest in environmental factors in thedevelopment of bipolar dosorder and schizophreniahave been notes in recent reports. Otherwise untill 2004there are no accurate studies in which the relationshipbetween psychological trauma and severe mental illness(SMI) is analyzed.Previous studies just detected that SMI and SPTDcomorbidity had a worse clinical outcome , a higher frequencyof achohol and drug abuse, more hospital admisions,more suicide temptations and a poorer laboralreinsertion.Very few studies about SMI and SPTD comorbititytreatment have been reported and a prospect in the clinicalreview about a traumatic events is propossed(AU)

[Factors associated to the development of Posttraumatic Stress Disorder]. / Factores asociados al desarrollo del trastorno por estrés post-traumático.

INTRODUCTION: Motor vehicle accidents appear to increase the risk of severe psychiatric morbidity in survivors. MATERIAL AND METHODS: We have studied retrospectively a population of 2,885 people who suffered an automobile accident in the city of Sabadell (Spain) in 1998. From these, we randomly selected a sample of fifty people who had developed PTSD, and a control group including the same amount of people. RESULTS: We reviewed the clinical and demographic differences in both samples and we found out that female gender and previous psychiatric morbidity are strongly related to the onset and course of PTSD.

Factores asociados al desarrollo del trastorno por estrés post-traumático / Factors associated to the development of Posttraumatic Stress Disorder

Introducción: Los accidentes de tráfico son un factor de riesgo de complicaciones psiquiátricas graves en los supervivientes. Material y métodos: Se realizó un estudio retrospectivo sobre una población de 2.885 personas que padecieron un accidente de automóvil en la ciudad de Sabadell (España) en 1998. De éstos, seleccionamos una muestra de cincuenta personas que habían desarrollado un Trastorno por Estrés Post Traumático (TEPT) y un grupo control del mismo número de personas. Resultados: Registramos las diferencias clínicas y demográficas que influían en el desarrollo del TEPT y encontramos que el sexo femenino y los antecedentes psiquiátricos previos estaban fuertemente relacionados con la aparición y el curso del TEPT (AU)