Deep-active-learning approach towards accurate right ventricular segmentation using a two-level uncertainty estimation.

The Right Ventricle (RV) is currently recognised to be a significant and important prognostic factor for various pathologies. Its assessment is made possible using Magnetic Resonance Imaging (CMRI) short-axis slices. Yet, due to the challenging issues of this cavity, radiologists still perform its delineation manually, which is tedious, laborious, and time-consuming. Therefore, to automatically tackle the RV segmentation issues, Deep-Learning (DL) techniques seem to be the axis of the most recent promising approaches. Along with its potential at dealing with shape variations, DL techniques highly requires a large number of labelled images to avoid over-fitting. Subsequently, with the produced large amounts of data in the medical industry, preparing annotated datasets manually is still time-consuming, and requires high skills to be accomplished. To benefit from a significant number of labelled and unlabelled CMRI images, a Deep-Active-Learning (DAL) approach is proposed in this paper to segment the RV. Thus, three main steps are distinguished. First, a personalised labelled dataset is gathered and augmented to allow initial learning. Secondly, a U-Net based architecture is modified towards efficient initial accuracy. Finally, a two-level uncertainty estimation technique is settled to enable the selection of complementary unlabelled data. The proposed pipeline is enhanced with a customised postprocessing step, in which epistemic uncertainty and Dense Conditional Random Fields are used. The proposed approach is tested on 791 images gathered from 32 public patients and 1230 images of 50 custom subjects. The obtained results show an increased dice coefficient from 0.86 to 0.91 with a decreased Hausdorff distance from 7.55 to 7.45.

Fully automatic brain tumor segmentation with deep learning-based selective attention using overlapping patches and multi-class weighted cross-entropy.

In this paper, we present a new Deep Convolutional Neural Networks (CNNs) dedicated to fully automatic segmentation of Glioblastoma brain tumors with high- and low-grade. The proposed CNNs model is inspired by the Occipito-Temporal pathway which has a special function called selective attention that uses different receptive field sizes in successive layers to figure out the crucial objects in a scene. Thus, using selective attention technique to develop the CNNs model, helps to maximize the extraction of relevant features from MRI images. We have also addressed two more issues: class-imbalance, and the spatial relationship among image Patches. To address the first issue, we propose two steps: an equal sampling of images Patches and an experimental analysis of the effect of weighted cross-entropy loss function on the segmentation results. In addition, to overcome the second issue, we have studied the effect of Overlapping Patches against Adjacent Patches where the Overlapping Patches show better segmentation results due to the introduction of the global context as well as the local features of the image Patches compared to the conventionnel Adjacent Patches. Our experiment results are reported on BRATS-2018 dataset where our End-to-End Deep Learning model achieved state-of-the-art performance. The median Dice score of our fully automatic segmentation model is 0.90, 0.83, 0.83 for the whole tumor, tumor core, and enhancing tumor respectively compared to the Dice score of radiologist, that is in the range 74% - 85%. Moreover, our proposed CNNs model is not only computationally efficient at inference time, but it could segment the whole brain on average 12 seconds. Finally, the proposed Deep Learning model provides an accurate and reliable segmentation result, and that makes it suitable for adopting in research and as a part of different clinical settings.

Fully Automatic Brain Tumor Segmentation using End-To-End Incremental Deep Neural Networks in MRI images.

BACKGROUND AND OBJECTIVE: Nowadays, getting an efficient Brain Tumor Segmentation in Multi-Sequence MR images as soon as possible, gives an early clinical diagnosis, treatment and follow-up. The aim of this study is to develop a new deep learning model for the segmentation of brain tumors. The proposed models are used to segment the brain tumors of Glioblastomas (with both high and low grade). Glioblastomas have four properties: different sizes, shapes, contrasts, in addition, Glioblastomas appear anywhere in the brain. METHODS: In this paper, we propose three end-to-end Incremental Deep Convolutional Neural Networks models for fully automatic Brain Tumor Segmentation. Our proposed models are different from the other CNNs-based models that follow the technique of trial and error process which does not use any guided approach to get the suitable hyper-parameters. Moreover, we adopt the technique of Ensemble Learning to design a more efficient model. For solving the problem of training CNNs model, we propose a new training strategy which takes into account the most influencing hyper-parameters by bounding and setting a roof to these hyper-parameters to accelerate the training. RESULTS: Our experiment results reported on BRATS-2017 dataset. The proposed deep learning models achieve the state-of-the-art performance without any post-processing operations. Indeed, our models achieve in average 0.88 Dice score over the complete region. Moreover, the efficient design with the advantage of GPU implementation, allows our three deep learning models to achieve brain segmentation results in average 20.87 s. CONCLUSIONS: The proposed deep learning models are effective for the segmentation of brain tumors and allow to obtain high accurate results. Moreover, the proposed models could help the physician experts to reduce the time of diagnostic.