1.
Beilstein J Org Chem
; 13: 2561-2568, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29259665
RESUMO
The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-b]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and subsequent intramolecular recyclization of the intermediate with the amino group involved.