RESUMO
BACKGROUND: The influenza vaccination is considered useful in preventing influenza and its complications, but its efficacy is variable. Recent data on clinical effectiveness of influenza vaccination in renal patients are lacking. MATERIALS AND METHODS: The clinical efficacy in our Hemodialysis Unit during the last three years has been evaluated: 287 patients have been vaccinated. The rate of vaccination achieved has been of 81.3%. RESULTS: The efficacy has been of 46.7%. The difference of efficacy noted among young people (< 60 years) and elderly (> 60 years) in general population is not observed among our hemodialyzed patients. Bronchopulmonary complications (radiographically proven) have been low: 1.7%. No mortality increase has been observed. CONCLUSIONS: These findings suggest that influenza vaccine can reduce the incidence and severity of influenza virus infections also among hemodialyzed patients.
Assuntos
Vacinas contra Influenza/imunologia , Influenza Humana/prevenção & controle , Falência Renal Crônica/imunologia , Diálise Renal , Vacinação , Adulto , Idoso , Estudos de Avaliação como Assunto , Feminino , Humanos , Incidência , Influenza Humana/complicações , Influenza Humana/diagnóstico por imagem , Influenza Humana/epidemiologia , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Radiografia , Estudos RetrospectivosRESUMO
In vitro experiments on actin polymerization in the presence of doxorubicin show that the rate of salt-induced actin assembly is negatively affected by the drug. The decreased amount of actin monomers keeping their ability to self-interact to give F actin (microfilaments) probably explains the reduction of assembly value. Drug action is dose-dependent and various discrepancies are explained by the limitations of the techniques used.
