RESUMO
The effects on liver blood flow caused by hydralazine were studied in 14 dogs. Hepatic artery and femoral artery blood flow were estimated with an electromagnetic flow meter. Total hepatic blood flow (THBF) was measured by 133Xenon clearance. Cardiac output (CO) was determined by intravenous injection of Cardio-Green. After 0.2 mg/kg of hydralazine total hepatic blood flow increased by 57%. The hepatic artery blood flow increased by 82% and portal blood flow by 58%. Cardiac output increased by about 50%, while total peripheral vascular resistance decreased. The results further suggest that hydralazine increases portal blood flow. Also the ratio THBF : CO increased. These findings together indicate a hydralazine-induced redistribution of cardiac output with a relatively increased proportion provided to the liver.
Assuntos
Hemodinâmica/efeitos dos fármacos , Hidralazina/farmacologia , Circulação Hepática/efeitos dos fármacos , Animais , Pressão Sanguínea/efeitos dos fármacos , Débito Cardíaco/efeitos dos fármacos , Cães , Resistência Vascular/efeitos dos fármacosRESUMO
The rate of postoperative wound infections was determined in a prospective study during one year in a newly opened University hospital. Protocols which were part of the routine care of the patients were used for recording of wound infections. This method of registration was simple and proved to be efficient with a failure rate of only 1%. The overall infection rate was 9%--after clean surgery 2.6%, potentially contaminated surgery 14% and contaminated surgery 16%. Old age, long preoperative hospital stay, emergency operations and long operative times were associated with high frequency of wound infections. The importance of continuous recording of wound infections in a surgical unit was emphasized.
