RESUMO
5-Deazaflavins and their homologues have been known as potential riboflavin antagonists, bioreductives, and compounds with potent antitumor activity. 2-Amino-4-methylquinoline-3-carbonitrile (2) was prepared as unreported starting material for several interesting 2-deoxo-5-deazalloxazine derivatives. Cyclization of 2 using formamide afforded the 2,4-deoxo-5-deazaalloxazine derivative 7, which was subjected to deamination with nitrous acid to give the 2-deoxo-5-deazaalloxazine (8). The compound 8 was also obtained via 13 by treating the latter with refluxing formic acid or formamide and used as a precursor for synthesis of several 2-deoxo-5-deazaalloxazines 18, 19, 20, 21 and 22. The pharmacological and biological properties of these compounds are still under investigation.
Assuntos
Flavinas/síntese química , Pteridinas/síntese química , Pirimidinonas/síntese química , Antineoplásicos/síntese química , Antineoplásicos/química , Antivirais/síntese química , Antivirais/química , Flavinas/química , Pteridinas/química , Pirimidinonas/química , Riboflavina/antagonistas & inibidores , Análise EspectralAssuntos
Estatura , Peso Corporal , Fatores Etários , Criança , Egito , Feminino , Humanos , Índia , Masculino , Fatores Sexuais , Estatística como Assunto , Estados UnidosRESUMO
PIP: Census data from Egypt in 1927, 1937, 1947, and 1960 indicate slow urbanization through 1937 and more rapid urbanization thereafter. There is a higher proportion of working age (15-44) people in urban areas and a higher proportion of males. Both fertility and mortality rates are higher in rural than in urban areas, but the rate of overall population growth is greater in urban areas. Figures from 4 recently industrialized urban areas (El-Mahalla, Kafr el-Dawar, Helwan, and Aswan) bear out the conclusions drawn from the general census figures.^ieng