[Changes in beta-N-acetylglucosaminidase activity of blood leukocytes in patients with arterial hypertension]. / Izmeneniia aktivnosti beta-N-atsetilgliukozaminidazy leikotsitov krovi u bol'nykh arterial'noi gipertenziei.

Activities of N-acetyl-beta-D-glucoseaminidase and of its A and B forms were studied in leukocytes of healthy persons and in patients with hypertension, hypertension combined with ischemic heart disease and in patients with ischemic heart disease. In healthy persons activity of the enzyme B form was increased with ageing. In the patients activities of both total N-acetyl-beta-D-glucoseaminidase and of its two forms were decreased. This decrease was especially distinct in the group of patients with hypertension.

[Contractile capacity of isolated flaps from the aorta of rats with stable arterial hypertension caused by the prolonged administration of cerebrosides]. / Sokratitel'naia sposobnost' izolirovannykh loskutov iz aorty krys so stoikoi arterial'noi gipertenziei, vyzvannoi dlitel'nym vvedeniem tserebrozidov.

A study was made of the contractility of smooth muscle cells of abdominal aorta strips of noninbred white rats with stable arterial hypertension induced by protracted intraperitoneal injection of cerebrosides isolated from cattle brain. It was demonstrated that as compared with normotensive animals, smooth muscle cells of the animals' arteries are characterized by the increased influx of extracellular calcium via slow potential-dependent calcium channels and hypersensitivity to noradrenaline and serotonin.

[Effect of glycosphingolipids on erythrocyte Na+,K+-ATPase activity]. / Vliianie glikosfingolipidov na aktivnost' Na+,K+-ATPazy éritrotsitov.

The total fractions of gangliosides and cerebrosides isolated from the tissue of human brain were studied for their effect on the Na+, K+-ATPase activity of native erythrocytes and their membranes. It is shown that gangliosides depending on time of their preincubation with the enzyme preparation and concentration produce both the activating and inhibiting action and cerebrosides--only the inhibiting one. Gangliosides inhibit the transport ATPase activity noncompetitively with respect to ATP and Na+ and competitively--to K+, cerebrosides inhibit it noncompetitively with respect to all ATPase activators.

[Cerebrosides as one of the factors regulating the functional state of the blood-vascular wall system]. / Tserebrozidy kak odin iz faktorov reguliatsii funktsional'nogo sostoianiia sistemy krov'-sosudistaia stenka.

During 4 months rats were given intraperitoneal injections of cerebrosides in a dose of 5 mg/kg bw. The measurements were taken of the arterial blood pressure and the function of blood cells. It has been demonstrated that as compared to the control, the experimental animals showed a significant elevation of the blood pressure, hyperaggregation of platelets and red cells, an increase in the ability of platelets to adhesion. It has been also disclosed that there was a decrease in the time of the occurrence of muscle fatigue and death under stress induced by forced dynamic work. The data obtained are of interest in the aspect of investigating the role played by glycolipids in the pathogenesis of cardiovascular diseases.

[Glycosphingolipid content and beta-galacto- and beta-glucosidase activity of the blood in acute myocardial infarction and postinfarction cardiosclerosis]. / Soderzhanie glikosfingolipidov i aktivnost' beta-galakto- i beta-gliukozidaz v krovi pri ostrom infarkte miokarda i postinfarktnom kardioskleroze.

Content of acid and neutral glycosphingolipids was distinctly higher in blood plasma and cells of patients with acute myocardium infarction as compared with healthy persons. In leukocytes of the patients activity of beta-galactosidase, exhibiting pH optimum at pH 3.6, was decreased with simultaneous activation of beta-galactosidase at pH 5.5 and of beta-glucosidase (at pH 4.0 and 5.5). Content of glycosphingolipids in blood decreased in post-infractional myocardial cardiosclerosis but remained sufficiently high as compared with controls. In the cardiosclerosis activity of beta-galactosidase was increased at pH 3.6 as compared with the acute infarction; this activity was decreased at pH 5.5 Activity of beta-glucosidase at the both pH values (pH 4.0 and 5.5) was decreased down to the normal values.

[Neutral glycolipids of blood in normal state and in hypertension]. / Neitral'nye glikolipidy krovi v norme i pri gipertonicheskoi bolezni.

Neutral glycolipids of blood constituted four main fractions both in healthy persons and in patients with hypertension. An increase in di- and trihexosylceramides in blood plasma and in monohexosylceramides from erythrocytes occurred simultaneously with elevation of total blood glycolipids in hypertension.