Antimicrobial activity of AgNO3 nanoparticles synthesized using Valeriana wallichii against ESKAPE pathogens.

The emergence of multidrug-resistant ESKAPE infections has emerged as a serious public health threat. Nosocomial infections are most often caused by ESKAPE bacteria. To combat multidrug-resistant ESKAPE, the research team used Valeriana Wallichii extracts and nanoparticles. The well diffusion technique was used to test antimicrobial activity on Muller Hinton agar medium. The FTIR, SEM and XRD techniques were used to characterize the nanoparticles synthesized in an environmentally benign manner. Both NPs performed better than extracts made with methanol and water in this investigation. The smallest zones of inhibition were shown against A. baumannii and Enterobacter cloacae, whereas the largest zones of inhibition were seen against E. faecium. However, NPs synthesized from shoot extracts exhibited remarkable effects against all MDR ESKAPE infections, with zones of inhibition of 23, 20, 12, 18, 22 and 14mm, respectively. Although E. faecium. had the largest inhibitory zone in both methanolic root and shoot extracts (19mm and 22mm, respectively), K. pneumonia and E. cloacae had the smallest zones when tested with these solvents. Water-based extracts inactivated multidrug-resistant bacteria. Our research show that extracts and nanoparticles have stronger antibacterial efficiency because biologically active substances including Terpenoids, Alkaloids, Phenol and Pholobutannins affect people and microbe.

Determination of chemical composition and investigation of potential of triphala powder in hypercholesterolemia in men in controlled randomized trial.

Hypercholesterolemia is a condition with elevated cholesterol and lipid profile. It is the leading reason behind myocardial infarction and coronary heart disease. It is observed in young people as well due to a sedentary lifestyle. Triphala powder has a hypolipidemic and anti-hypercholesterolemia effect. This study was designed to investigate the effect of triphala powder against hypercholesterolemia. This study also examined Triphala powder's chemical composition. Total phenolic and flavonoid content were examined. Encapsulated 400 mg and 600 mg Triphala powder were given to treatment groups I and II. Lipid profile parameters were measured and compared at 0 weeks and 10th weeks in all groups. All results were analyzed using ANOVA in IBM SPSS Statistics 20. Results of proximate analyses have shown that Okra pod powder contains moisture 12.27%, ash 11.25%, nitrogen-free extract 45.93%, crude protein 13.37%, crude fat 2.95% and crude fiber 14.23%. Mineral analysis showed that iron and manganese are major minerals in triphala powder. Triphala powder showed a significant reduction in lipid profile parameters in hypercholesterolemia. All results are taken significantly at p<0.05.