Malignancy rate in thyroid nodules classified as Bethesda category III (AUS/FLUS).

BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology is the standard for interpreting fine needle aspiration (FNA) specimens. The "atypia of undetermined significance/follicular lesion of undetermined significance" (AUS/FLUS) category, known as Bethesda Category III, has been ascribed a malignancy risk of 5-15%, but the probability of malignancy in AUS/FLUS specimens remains unclear. Our objective was to determine the risk of malignancy in thyroid FNAs categorized as AUS/FLUS at a comprehensive cancer center. METHODS: The management of 541 AUS/FLUS thyroid nodule patients treated at Memorial Sloan-Kettering Cancer Center between 2008 and 2011 was analyzed. Clinical and radiologic features were examined as predictors for surgery. Target AUS/FLUS nodules were correlated with surgical pathology. RESULTS: Of patients with an FNA initially categorized as AUS/FLUS, 64.7% (350/541) underwent immediate surgery, 17.7% (96/541) had repeat FNA, and 17.6% (95/541) were observed. Repeat FNA cytology was unsatisfactory in 5.2% (5/96), benign in 42.7% (41/96), AUS/FLUS in 38.5% (37/96), suspicious for follicular neoplasm in 5.2% (5/96), suspicious for malignancy in 4.2% (4/96), and malignant in 4.2% (4/96). Of nodules with two consecutive AUS/FLUS diagnoses that were resected, 26.3% (5/19) were malignant. Among all index AUS/FLUS nodules (triaged to surgery, repeat FNA, or observation), malignancy was confirmed on surgical pathology in 26.6% [CI 22.4-31.3]. Among AUS/FLUS nodules triaged to surgery, the malignancy rate was 37.8% [CI 33.1-42.8]. Incidental cancers were found in 22.3% of patients. On univariate logistic regression analysis, factors associated with triage to surgery were younger patient age (p<0.0001), increasing nodule size (p<0.0001), and nodule hypervascularity (p=0.032). CONCLUSIONS: In patients presenting to a comprehensive cancer center, malignancy rates in nodules with AUS/FLUS cytology are higher than previously estimated, with 26.6-37.8% of AUS/FLUS nodules harboring cancer. These data imply that Bethesda Category III nodules in some practice settings may have a higher risk of malignancy than traditionally believed, and that guidelines recommending repeat FNA or observation merit reconsideration.

Establishing a training program for residents in robotic surgery.

OBJECTIVES/HYPOTHESIS: To develop a program for teaching robotic skills to residents. To assess the development of proficiency in basic robotic surgical skills in a resident cohort. STUDY DESIGN: Prospective educational project using a commercially available surgical robot. Residents use a surgical robot to complete a designated set of tasks intended to simulate surgical maneuvers. Performance is analyzed for errors and total time of procedure. METHODS: Otolaryngology residents are introduced to robotic surgery with a tutorial on the usage of the da Vinci Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA). Participants perform defined exercises accomplishing the following tasks: circular pin transfer, simultaneous bimanual carrying, precision bead drop, needle passing, and suture tying. Performance of these tasks can be quantitatively assessed. RESULTS: An educational program for teaching residents basic robotic skills can easily be introduced into a residency program. Resident progress in acquiring robotic surgical skills can be measured. The analysis of variance for composite score revealed statistically significant effects for task (F(4,24) = 8.11, P < .01) and trial (F(2,12) = 5.71, P < .01). CONCLUSIONS: Robotic surgery will likely become an integral part of otolaryngologic surgical practice. Training programs in robotic surgery need to be formally established in residency programs. We present a preliminary program for introducing robotic surgical skills in residency training.