Assuntos
Animais Recém-Nascidos/fisiologia , Sistema Hipotálamo-Hipofisário/fisiologia , Inibinas/farmacologia , Testículo/fisiologia , Animais , Hormônio Foliculoestimulante/metabolismo , Hormônio Liberador de Gonadotropina/metabolismo , Sistema Hipotálamo-Hipofisário/efeitos dos fármacos , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Espermatogênese/efeitos dos fármacos , Testículo/anatomia & histologia , Testículo/efeitos dos fármacosAssuntos
Inibinas/farmacologia , Transcrição Gênica/efeitos dos fármacos , Animais , Bovinos , Sistema Livre de Células , Cromatografia em Gel , Hormônio Foliculoestimulante/metabolismo , Fígado/metabolismo , Masculino , Receptores de Superfície Celular/metabolismo , Receptores do FSH , Ovinos , Testículo/análiseRESUMO
Inhibin (Inh) and testosterone (T) were administered to adult male rats for 32 days to evaluate their effect on spermatogenesis. Fifty micrograms of Inh was injected subcutaneously twice daily, and T was administered as Silastic implants 2.5 cm in length. Weights of testes and epididymides were significantly decreased in (Inh + T)- and T-treated groups, but not in Inh-treated rats. Although Inh alone could suppress both the testicular and the epididymal sperm count, maximum suppression was observed in the (Inh + T)-treated group. The effect on the epididymal sperm count, however, was pronounced. The accessory organ weights remained unaffected in all treated groups. Chronic administration of Inh and T results in partial impairment of spermatogenesis.
Assuntos
Inibinas/administração & dosagem , Espermatogênese/efeitos dos fármacos , Testosterona/administração & dosagem , Animais , Depressão Química , Epididimo/anatomia & histologia , Inibinas/farmacologia , Masculino , Tamanho do Órgão/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Ovinos , Contagem de Espermatozoides , Testículo/anatomia & histologia , Testosterona/farmacologia , Fatores de TempoRESUMO
A specific antiserum to ovine follicle stimulating hormone (AS/FSH) raised in rabbits and administered to prepubertal mice from days 5 to 35 of age, inhibited intermediate and type B spermatogonia. Development of spermatocytes, spermatids, and spermatozoa was affected, indicating a role for FSH in the initiation of spermatogenesis. Decrease in the testicular and epididymal weights, but not that of seminal vesicles and ventral prostate, demonstrated the specific action of AS/FSH. Reduction in the weights of the epididymis in AS/FSH-injected mice accompanied by the absence of spermatozoa in the lumen suggests a possible role for FSH in spermiation.
Assuntos
Hormônio Foliculoestimulante/deficiência , Maturidade Sexual , Espermatogênese , Animais , Feminino , Masculino , Camundongos , Tamanho do Órgão , Testículo/patologiaRESUMO
Injection of antiserum to ovine FSH on the day of proestrus could inhibit ovulation in the next cycle. Inhibin preparation purified from sheep ovaries failed to affect ovulation in mice. Suppression of FSH by this preparation of inhibin during early pregnancy reversed the mitotic index. Administration of inhibin during the peri-implantation period terminated pregnancy in mice. The inhibin preparation decreases FSH in circulation which in turn may possibly reduce ovarian estrogens, thereby inhibiting pregnancy.
