Linking stress with urocortin in rats.

The corticotropin-releasing factor neuropeptides (CRH and UCN-1,2,3), as well as spexin, contribute to the control of energy balance and limit food intake in mammals. However, the role of these neuropeptides in chronic variable stress remains unknown. The effect of chronic varied stress on circulating corticosterone levels and urocortin expression levels in the brains of experimental rats was studied in this study. Rats were subjected with 28 days long term stress protocol, end of stress protocol experimental and control animal organs isolated, brain urocorcortin-1,2,3 expression by RT-PCR and serum corticosterone by ELISA method. UCN levels in the brain were altered in rats subjected to prolonged varied stress. Furthermore, corticosterone levels were elevated as a result of the same urocortin expression pattern, indicating that urocortin expression is controlled by glucocorticoids via a glucocorticoid-responsive element (GRE). Thus, data shows that hypothalamus-pituitary-adrenal (HPA) axis, also known as the LHPA axis, and limbic system are both stimulated by stress, which is reflected in the form of elevated corticosterone levels, according to the genes UCN1, 2, and 3.

Accessory heads of biceps brachii muscle its embryogenesis and clinical implications: Cadaveric study.

Background: Biceps brachii is an elongated two-headed fusiform muscle of the anterior compartment of the arm which crosses the shoulder as well as the elbow joint. It assists in flexion of the shoulder joint and elbow joint and powerful supinator of the forearm. It also assists in the abduction of the shoulder joint. Accessory heads of biceps brachii muscle not only give additional strength to the joints, at the same time, they may also simulate soft-tissue tumors that can result in neurovascular compression. Aims and Objectives: Accordingly, the aim of this study was designed to evaluate the prevalence of accessory heads of biceps brachii muscle in human cadavers. Materials and Methods: This study was conducted on 107 formalin embalmed human cadavers (male 62 and 45 female), and dissections were performed in accordance with the institutional ethical standards and the Indian Anatomy Act. Results: Out of 107 cadavers, three-headed biceps brachii was noted in 18 cadavers (16.82%) associated with the unusual course of musculocutaneous nerve. Rare and unusual unilateral five-headed biceps brachii was noted in one male cadaver (0.93%). All accessory heads noted in this study were supplied by the separate branches of musculocutaneous nerve except the humeral head of five-headed biceps, which was supplied by the radial nerve. Conclusion: Awareness of these anatomical variations, knowledge is necessary for radiologists, anesthetists, physiotherapists, and orthopedic surgeons to avoid complications during various radiodiagnostic procedures or surgeries of flexor deformities of the upper arm and forearm.

Résumé Contexte: Le biceps brachial est un muscle allongé fusiforme à deux têtes de la loge antérieure du bras qui traverse l'épaule ainsi que l'articulation du coude. Il aide à la flexion de l'articulation de l'épaule et du coude et supinateur puissant de l'avant-bras. Il aide également à l'abduction de l'articulation de l'épaule. Les têtes accessoires du muscle biceps brachial donnent non seulement une force supplémentaire aux articulations, en même temps, ils peuvent également simuler des tumeurs des tissus mous pouvant entraîner une compression neurovasculaire. Buts et objectifs: En conséquence, le but de ce étude a été conçue pour évaluer la prévalence des têtes accessoires du muscle biceps brachial chez les cadavres humains. Matériels et méthodes: ce étude a été menée sur 107 cadavres humains embaumés au formol (hommes 62 et 45 femmes), et des dissections ont été réalisées dans conformément aux normes éthiques institutionnelles et à la loi sur l'anatomie indienne. Résultats: Sur 107 cadavres, biceps brachial à trois têtes a été notée sur 18 cadavres (16,82 %) associée à l'évolution inhabituelle du nerf musculo-cutané. Unilatérale rare et inhabituelle Un biceps brachial à cinq têtes a été noté sur un cadavre masculin (0,93 %). Toutes les têtes accessoires notées dans cette étude ont été fournies par le branches du nerf musculo-cutané à l'exception de la tête humérale du biceps à cinq têtes, qui était alimentée par le nerf radial. Conclusion: Conscience de ces variations anatomiques, une connaissance est nécessaire aux radiologues, anesthésistes, kinésithérapeutes, et chirurgiens orthopédistes pour éviter les complications lors de diverses procédures de radiodiagnostic ou de chirurgies des déformations des fléchisseurs de la partie supérieure bras et avant-bras. Mots-clés: Asymétrie, tumeurs dermoïdes, hypertrophie et lipome, névralgie mandibulaire.

Lumbosacral transitional vertebrae: a case report and clinical implications / Vértebras lumbosacras de transición: reporte de un caso e implicancias clínicas

A lumbosacral transitional vertebra is a rare congenital anomaly which occurs because of defect in the segmentation of the lumbosacral spine during development. During routine osteology classes for the medical students at the Kasturba Medical College, Mangalore, India, one of the sacra showed the fusion of the fifth lumbar vertebra with the sacrum. The specimen showed an incomplete fusion (sacralization) on the left side and the transverse process was of the large butterfly shape, while on the right it was about the usual size. Though this variation is well known, the details of this anomaly are rarely reported in the anatomical literature. Since there is a strong relationship between the lumbosacral transitional vertebrae and low back pain, this anomaly has gotten increased clinical interest. So this case was studied in detail with relevant review of literature and its surgical, radiological implications are discussed.

Una vértebra de transición lumbosacra es una anomalía congénita rara que se produce debido a defectos en la segmentación de la columna lumbosacra durante el desarrollo. Durante una clase de osteología para estudiantes de medicina en Kasturba Medical College, Mangalore, India, una de las regiones sacras mostró fusión de la quinta vértebra lumbar con el sacro. El especimen mostró fusión incompleta (sacralización) en el lado izquierdo y el proceso transverso tenía forma de mariposa grande, mientras que en el derecho se observó de tamaño normal. A pesar que esta variación es conocida, los detalles de esta anomalía rara vez son reportados en la literatura anatómica. Puesto que existe una fuerte relación entre las vértebras de transición lumbosacra y el dolor de espalda baja, esta anomalía tiene gran interés clínico. Este caso fue estudiado en detalle con la revisión pertinente de la literatura, y son discutidas sus implicancias quirúrgicas y radiológicas.