RESUMO
Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury. These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats. We found that 3-O-[(dodecylcarbonyl)methyl]ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.
Assuntos
Antiarrítmicos/farmacologia , Arritmias Cardíacas/prevenção & controle , Ácido Ascórbico/análogos & derivados , Sequestradores de Radicais Livres , Traumatismo por Reperfusão Miocárdica/complicações , Anestesia , Animais , Arritmias Cardíacas/etiologia , Ácido Ascórbico/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Cobaias , Átrios do Coração/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Técnicas In Vitro , Peroxidação de Lipídeos/efeitos dos fármacos , Microssomos Hepáticos/metabolismo , Ratos , Ratos Endogâmicos , Verapamil/farmacologiaRESUMO
In this paper a fiber laser plate, consisting of many fiber lasers in a form similar to an ordinary optical fiber plate, is described. The fiber laser plate, when end-pumped, can emit a laser light image corresponding to a 2-D transparency. The abrupt change of output intensity with excitation energy shows that the plate is attractive as an optical threshold device.
