[Screening study methods use for substantiation of immune modulating therapy of hypergic inflammatory process in maxillofacial region].

With the help of flow cytometry it was shown that for patients with hypergic inflammatory process in maxillofacial region the reduction of lymphocytes relative number was typical as well as their absolute number reduction. Direct and very strong correlation was established between absolute lymphocytes number in peripheral blood and absolute number of CD3 and CD4 lymphocytes subpopulations by correlation analyses. The reduction of absolute lymphocytes number in peripheral blood let speak with more probability about the reduction of the number of CD3 and CD4 lymphocytes subpopulations and diagnose secondary immune deficit.

Interaction peculiarities between microbial cenosis and local immunity of periodontium of humans under extreme conditions.

The investigations were directed at finding out the peculiarities of both periodontal microflora and local immunity under extreme conditions (spaceflight, saturation diving, antiorthostatic hypokinesia). The obtained results revealed different kinds of interactions amongst which saturation diving resulted in the most severe decrease of commensale microflora level, decrease of local immunity and appearance of periodontal pathogens.

[Role of phagocytosis activation in the mechanism of therapeutic effect of medical ozone in patients with sluggish purulent inflammations of maxillofacial soft tissues]. / Rol' aktivatsii fagotsitoza v mekhanizme lechebnogo deistviia meditsinskogo ozona u bol'nykh s vialotekushchimi gnoinymi vospalitel'nymi protsessami miagkikh tkanei cheliustno-litsevoi oblasti.

Sixty-three patients with local sluggish suppurative inflammations of maxillofacial soft tissues were examined. Medical ozone was added to the treatment protocols of 30 of these patients. Before treatment peripheral blood leukocyte phagocytic activity was decreased in 54 patients, which corresponded to clinical form of a sluggish inflammation. Traditional therapy did not appreciably change the level of phagocytosis. Addition of medical ozone exposure to therapy promoted normalization of leukocyte phagocytic activity and accelerated liquidation of inflammation.

[The syndrome of reduced colonization of periodontium tissues during long-term anti-orthostatic hypokinesia]. / Sindrom snizheniia kolonizatsionnoi rezistentnosti tkanei parodonta v usloviiakh prodolzhitel'noi antiortostaticheskoi gipokinezii.

Effects of antiorthostatic hypokinesia (AOH, -6 degrees) during 60 and 120 days on the parodontium in 10 human subjects aged 24-33 yr. have been studied. Clinical, functional, immunologic, and microbiological analyses were performed 30 days prior to, on days 7 and 30, and on day 7 since the experiment. The parodontium was assessed by relevant indices, immunoglobulines in the oral fluid, and bacteriological parameters determined with the anaerobic cultivation technique. AOH was found to reduce the colonisation resistance of the parodontium due to obviously, the immunologic inertia and consequent changes in the qualitative composition of microflora. It is concluded that the parodontium responds to extreme conditions by replacement of the commensal microflora by opportunistic and obligate parodontosis pathogens.

[Relationship between nonspecific, immunologic reactivity of the body and the type of course of an acute inflammatory process]. / Sviaz' mezhdu nespetsificheskoi, immunologicheskoi reaktivnost'iu organizma i tipom techeniia ostrogo vospalitel'nogo protsessa.

By using the results of clinical, laboratory, and immunological studies, the authors show that the type (normoergic, hypoergic, hyperergic) of an inflammatory response is related to the parameters of nonspecific and immunological responsiveness of patients with pyo-inflammation in the maxillofacial region. The hypoergic inflammatory response is characterized by the least responsiveness mainly to its cellular link. The hyperergic inflammatory reaction is chiefly caused by considerably enhanced phagocytosis.

[Indications for the use of tactivin in the combined treatment of phlegmons of the maxillofacial area]. / Pokazaniia k primeneniiu taktivina v kompleksnom lechenii flegmon cheliustno-litsevoi oblasti.

The effects of subcutaneous and endolymphatic tactivin (in doses of 1 ml of 0.01% solution daily for 7 days) on clinical and immunological parameters were studied in patients with acute inflammations in the maxillofacial area, running a normo-, hypo-, and hyperergic course. Tactivin accelerated the arrest of inflammatory process and improved the patients' status, particularly so in cases with the hypo- and hyperergic inflammations. The key role in the mechanism of the drug action is played by increase of the immunoregulatory index, which reflects the increasing resistance of the body.

[Study of the immunotropic properties of theophylline in lymphocyte culture]. / Izuchenie immunotropnykh svoistv teofillina v kul'ture limfotsitov.

The effect of theophylline on the activation of suppressor cells by histamine was studied in the experiments with mononuclear cells of blood of patients with bronchial asthma and healthy donors. Theophylline (1-5 micrograms/ml) was shown to be able of activating suppressed function of cells of the patients. Incubation of mononuclear cells of the healthy donors with theophylline did not change the process of suppressor formation in vitro.