RESUMO
Microbial organisms express pathogen-associated molecular patterns (PAMPs) that can stimulate expression of proinflammatory mediators following ligation of pathogen recognition receptors. However, both commensal organisms and pathogens can express PAMPs. The immune system can distinguish between commensals and pathogens in part through secretion of the key inflammatory cytokines interleukin (IL)-1beta and IL-18. A PAMP such as lipopolysaccharide can induce production of intracellular pro-IL-1beta and pro-IL-18, but not their secretion. A second "danger signal", derived from host-cell molecules that are released from stressed or infected cells, or detected as a PAMP that is present in the cytosol, can stimulate assembly of an inflammasome that activates the protease caspase-1. Caspase-1, in turn, is responsible for processing and secretion of the mature IL-1beta and IL-18. Many diverse ligands leading to inflammasome activation have been identified, but the cell signaling pathways initiated by the ligands tend to converge on a small set of common mechanisms.
Assuntos
Proteínas Adaptadoras de Transdução de Sinal/fisiologia , Proteínas Reguladoras de Apoptose/fisiologia , Infecções Bacterianas/imunologia , Proteínas Adaptadoras de Sinalização CARD/fisiologia , Proteínas de Ligação ao Cálcio/fisiologia , Proteínas de Transporte/fisiologia , Transdução de Sinais/fisiologia , Animais , Proteínas de Ligação a DNA , Humanos , Interleucina-1beta/biossíntese , Proteína 3 que Contém Domínio de Pirina da Família NLR , Proteínas NLR , Proteínas Nucleares/fisiologia , Potássio/metabolismo , Espécies Reativas de Oxigênio/metabolismoRESUMO
A rare case of abscess of the corpus cavernosum is described. The patient was treated successfully by surgical drainage and antibiotic therapy. A right penile deviation and a relatively poor erection were reported by the patient 6 weeks postoperatively but he did not require further surgery. The possible causes, diagnosis and treatment of this rare disease are discussed.
