1.
Org Lett
; 20(13): 3815-3818, 2018 07 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29897244
RESUMO
A novel nickel-catalyzed approach to synthesize ortho-arylated and alkenylated benzamides in good to high yields via a denitrogenative cross-coupling reaction of 1,2,3-benzotriazin-4(3 H)-ones with organoboronic acids is described. The reaction proceeds through a five-membered azanickelacyclic intermediate with the extrusion of a nitrogen molecule. Moreover, the resulting ortho-arylated benzamides were successfully converted into synthetically useful substituted fluorenones and ortho-arylated benzylamine derivatives in high yields.