RESUMO
Background Management of a febrile patient is based on understanding the pathophysiology of an abnormal temperature and temperature regulation, impacts of fever, and its treatment. In the current study, we aimed to characterize and compare the epidemiological, etiologic, microbiological, serological, clinical, and outcome traits of febrile patients with acute neutropenia admitted to a tertiary care center in Western Maharashtra. Methods Adult patients with a history of fever of less than two weeks' duration and without any immunosuppressive state were screened with predefined inclusion and exclusion criteria. General and demographic information (age and gender), and clinical examinations (type and duration of fever) were recorded. Biochemical, hematologic (total and differential cell counts), and immunologic measurements (rapid malaria, dengue, Leptospira, and viral hepatitis antigen antibodies) were performed. Data were analyzed using an appropriate statistical package. Results A total of 403 (214 males) young adults (aged: 29±11 years) with clinical presentation of fever were studied. The majority (n=361, 89.6%) had low-grade continuous fever with an average duration of 3±1 (mean±standard deviation (SD)) days. Headache and myalgia were the common symptoms present, and patients had an average hospital stay of 4±1 days. Dengue (55%) was the most common cause of febrile neutropenia, and all patients recovered well without antibiotics and granulocyte colony-stimulating factor. The mean C-reactive protein (CRP) level was 61.4±4.4 mg/L. CRP and procalcitonin (PCT) were directly correlated with the degree of neutropenia and inversely correlated with total leucocyte count (TLC). Conclusions It was highlighted from this study that antibiotics are not necessary for viral infections that have been diagnosed to stop the development of secondary bacterial infections. A clinician should be aware of "when not to use antibiotics," or the world will soon have to deal with superbugs.
RESUMO
Diabetes mellitus (DM) is a clinical syndrome associated with deficiency of insulin secretion or action. It is considered one of the largest emerging threats to health in the 21st century. Besides the classical complications of the disease, DM has been associated with reduced response of T cells, neutrophil function, and disorders of humoral immunity. Consequently, DM increases the susceptibility to infections, both the most common ones as well as those that almost always affect only people with DM (e.g. rhinocerebral mucormycosis). The present study was done with an objective to study the infections in type 2 Diabetes Mellitus. MATERIAL: The study was conducted in Padmashri DY Patil Hospital and Research centre, Pimpri, Pune from Sept 2020 to Aug 2021. A total of 100 patients of Type 2 Diabetes Mellitus were included and their infections associated with type 2 Diabetes Mellitus were studied. OBSERVATION: Infections associated with Diabetes Mellitus were Urinary Tract Infections, Dental caries, Skin infections like Tinea, Carbuncle and furuncle, Pneumonia, Emphysematous pyelonephritis, Diabetic foot. CONCLUSION: The results of present study showed that many patients with Diabetes Mellitus is associated with urinary tract infections. This was corresponding with studies conducted by Ludwig E. The most common infections associated with type 2 Diabetes Mellitus were Urinary Tract Infections, Skin infections, Pneumonia, Emphysematous pyelonephritis, Diabetic foot.
