Utilization of plastic waste as replacement of natural aggregates in sustainable concrete: effects on mechanical and durability properties.

The study presents the mechanical and durability properties of concrete made up of recycled-waste-polyethylene (PE) and waste-polyethylene-terephthalate (PET)-based aggregate as replacement of natural fine and coarse aggregate, respectively. For this purpose, compressive strength, sorptivity, water permeability, aggressive exposure in acid, base, marine and wastewater, impact resistance, abrasion loss including surface and Cantabro, gas permeability, rapid chloride penetration test (RCPT), elevated temperature and leachability test of microplastic were performed. The experimental works were performed for different volumetric replacement (0-40%) of natural fine and coarse aggregates by PE and PET made aggregate respectively for different curing periods. The experimental results revealed that the sorptivity of PE-based concrete was lowest. Water permeability coefficient signified that with the increase of percentage of PET water permeability increased. In case of aggressive exposure test, the percentage of residual mass and residual strength for all replacement was decreased with the increase in exposure period. Further, impact resistance test result signified that energy absorption increased with the increase of PE and PET percentages. Cantabro and surface abrasion weight loss showed similar trend. Carbonation depth was increased with increasing percentages of PE and PET signified strength decreased with increase of percentages of PE and PET when subjected in CO2. RCPT test results demonstrated that with increase of PE and PET percentages chloride ion penetrability was reducing. It is observed that below 100 °C temperature, compressive strength of all mix proportions was not affected with elevated temperature. Moreover, the PET-based concrete showed no presence of microplastic in case of leachability test.

Pentoxifylline Plus Prednisolone versus Pentoxifylline Only for Severe Alcoholic Hepatitis: A Randomized Controlled Clinical Trial.

BACKGROUND: Prednisolone and pentoxifylline (PTX) have been shown to be individually useful in severe alcoholic hepatitis with Maddrey discriminant function (MDF) score ≥32. Previous report suggests that PTX is probably superior to prednisolone alone. However the efficacy of PTX and prednisolone combination over PTX alone in the management of acute alcoholic hepatitis (MDF score ≥32) is yet unrevealed. AIM: The present study was initiated to find out the efficacy of combined pentoxifylline and prednisolone versus PTX alone in acute alcoholic hepatitis in respect of short and intermediate term outcomes. SUBJECTS AND METHODS: A total of 124 patients with severe alcoholic hepatitis (MDF score ≥ 32) initially were evaluated. 62 patients who fulfilled the inclusion and exclusion criteria were randomized and divided into 2 groups. Group 1 received PTX only, whereas Group 2 received PTX plus Prednisolone. The total duration of follow-up was 12 months. Student's t-test, Chi-square test, the Kaplan-Meier methods were used for statistical analysis. RESULTS: A total of 60 patients, 30 in each group were available for final analysis. In Group-1, 6 patients expired at the end of 1 year (5 within 3 months and another after 3 months). In Group 2, 10 patients expired at the end of 1 year (9 within 3 months and another after 3 months). Though survival probability is higher among Group 1 patients but the difference is not statistically significant. CONCLUSION: The combination of PTX plus Prednisolone yields no additional benefit in terms of mortality and morbidity from that of PTX monotherapy.

Androgen-induced neurite outgrowth is mediated by neuritin in motor neurones.

In the brain, the spinal cord motor neurones express the highest levels of the androgen receptor (AR). Experimental data have suggested that neurite outgrowth in these neurones may be regulated by testosterone or its derivative 5alpha-dihydrotestosterone (DHT), formed by the 5alpha-reductase type 2 enzyme. In this study we have produced and characterized a model of immortalized motor neuronal cells expressing the mouse AR (mAR) [neuroblastoma-spinal cord (NSC) 34/mAR] and analysed the role of androgens in motor neurones. Androgens either activated or repressed several genes; one has been identified as the mouse neuritin, a protein responsible for neurite elongation. Real-time PCR analysis has shown that the neuritin gene is expressed in the basal condition in immortalized motor neurones and is selectively up-regulated by androgens in NSC34/mAR cells; the DHT effect is counteracted by the anti-androgen Casodex. Moreover, DHT induced neurite outgrowth in NSC34/mAR, while testosterone was less effective and its action was counteracted by the 5alpha-reductase type 2 enzyme inhibitor finasteride. Finally, the androgenic effect on neurite outgrowth was abolished by silencing neuritin with siRNA. Therefore, the trophic effects of androgens in motor neurones may be explained by the androgenic regulation of neuritin, a protein linked to neurone development, elongation and regeneration.

Burning charcoal: an indigenous method of committing suicide in Hong Kong.

BACKGROUND: Carbon monoxide (CO) poisoning by burning charcoal has become one of the most common ways of committing suicide in Hong Kong since late 1998. The evolution of the phenomenon was explored in the current study. METHOD: Information about completed suicides between January 1996 and December 1999 was obtained from the Hong Kong death registry and hospital authority, and information about ambient temperature and humidity was obtained from the Hong Kong Observatory. News on completed suicides by burning charcoal was collected by computer search using the data bank of 6 major Hong Kong newspapers. The data were analyzed. RESULTS: CO poisoning by burning charcoal rose from 0% of all Hong Kong suicides in 1996 and 1997 to 1.7% in 1998 and 10.1% in 1999. The monthly incidence rate bore a reciprocal relationship with the ambient temperature. Suicidal pacts were overrepresented, and past history of mental illness was uncommon. Both demographic and clinical features of suicides by burning charcoal resembled those of suicides by domestic gas poisoning. The overall suicide rate remained unchanged in the above period. CONCLUSION: Suicide by burning charcoal is a new variant of domestic gas poisoning. A host of biopsychosocial and ethnological factors are responsible for the birth and indigenization of the method.