RESUMO
Starting from 14C-p-fluorobenzoic acid the synthesis of 14C-labelled 2-amino-3-ethoxycarbonylamino-6-(p-fluorobenzylamino)-pyridi ne maleate (flupiritine maleate, D 9998) is described.
Assuntos
Aminopiridinas/síntese química , Radioisótopos de Carbono , Fenômenos Químicos , Química , Marcação por IsótopoRESUMO
The tritiation of (+)-(R)-alpha-((S)-1-[(3,3-di-3-thienylallyl)amino]-ethyl)-benzylalcohol (tinofedrine) is reported. The introduction of tritium was effected by partial hydrogenation of propiolic acid ester to the corresponding tritiated acrylic ester.
Assuntos
Tiofenos/síntese química , Fenômenos Químicos , Química , Marcação por Isótopo/métodos , TrítioRESUMO
Synthesis of radioactively labelled 7-(3-[2-(3,5-dihydroxy-phenyl)-2-hydroxy-ethylamino]-propyl)-theophylline (reproterol) as needed for pharmacokinetic examinations, is described. The 14C-malonic diethyl ester was proven to be the suitable starting compound. The synthesis of the tritium-labelled reproterol is briefly described.
