[Allogeneic implantation of the tendon tissue sterilized with gaseous ethylene oxide in experiment]. / Alloimplantatsiia sukhozhil'noi tkani, sterilizovannoi gazoobraznoi okis'iu étilena, v éksperimente.

The implantation of the allo-tendon tissue sterilized with gaseous ethylene oxide was carried out in 51 while rats. Results of histological investigations are described and a comparative estimation is given of durability of the properties of ethyleneoxide sterilized allotendons of the human with the anterior cruciate ligament and dermal tissue. A conclusion is made that it is possible to use the tendon allotransplants in clinical practice.

[The structure of the hyaline cartilage in the plastic substitution of articular surface defects (an electron microscopic study)]. / Stroenie gialinovogo khriashcha pri plasticheskom zameshchenii defektov sustavnoi poverkhnosti (élektronno-mikroskopicheskoe issledovanie).

Results of the transplantation of the hyaline (articular) cartilage with the subchondral layer were studied in 100 mature rabbits. The transplants were treated by different methods. It was found that the hyaline cartilage of the articular transplants does not take part in reparative processes. It undergoes either partial or complete resolution. The resolution processes in auto- or allotransplantation of fresh transplants proceed longer and are characterized by gradual death of cell elements and by a destruction of the collagen structures. The demineralized osteochondrous transplants preserved in a week solution of formalin with kanamycin are closer to them in their terms and character of transformation. They are the material which should be recommended as most perspective for arthroplasty.

[The procurement of demineralized cranial transplants and their clinical use]. / Zagotovka demineralizovannykh kraniotransplantatov i ikh primenenie v klinike.

Demineralized cranial transplants of allogenic origin when transplanted to 49 neurosurgical patients with defects of the skull cap of not more than 50 cm2 area gave positive results by liquidating the corresponding symptoms. High bioplastic quality of such transplants allow them to be recommended for wide use in clinics.

[Experience with the clinical use of demineralized bone autografts in traumatology and orthopedics]. / Opyt klinicheskogo primeneniia demineralizovannykh kostnykh allotransplantatov v travmatologii i ortopedii.

The authors analyse the results of clinical application of osseous allografts demineralized by 1, 2-2, 4-3, 6 N solutions of hydrochloric acid. Of 92 patients with various pathologies of the locomotor system the postoperative results were positive in 85 cases (92.4%) and negative in 7 cases (7.6%). The analysis has demonstrated that the negative results were not connected with the kind of the osteoplastic material.

[Use of demineralized allogeneic bone transplants for plastic surgery of osteomyelitic cavities]. / Primenenie demineralizovannykh kostnykh allotransplantatov dlia plastiki osteomieliticheskikh polostei.

Plasty of osteomyelitic cavities with demineralized bone transplants was performed in 55 patients. Different methods of the bone cavity plasty were used with regard for the state of soft tissues surrounding the pathological focus, changes in the purulent focus. In most of the patients (41) the cavity was filled up with the demineralized bone transplant formed with special reference to the size of the bone wound. In the other 14 patients with false joints complicated by osteomyelitis the bone allotransplant was put in the area of the defect as a duplicator. Good results were obtained in 53 (96.4%) patients.

[Results of using autologous and demineralized allogeneic bone transplants in reconstructive operations on the mandible in children with the syndrome of the first and second branchial arches]. / Rezul'taty primeneniia auto- i demineralizovannykh kostnykh allotransplantatov pri rekonstruktivnykh operatsiiakh nizhnei cheliusti u detei s sindromom pervoi i vtoroi zhabernykh dug.

A comparative clinico-roentgenological assessment of results of transplantation of auto- and allogenic demineralized transplants in reconstructive operations on the mandible was made in 58 children with the syndrome of the first and second branchial arches aged from 1 to 14 years. It was found that the substitution of the transplants by a new bone tissue was developing similarly. Allogenic bone transplants have a number of advantages over autotransplants: a simpler treatment and modelling the absence of an additional trauma to the child and a shorter duration of the operation.

[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]. / Klonirovanie i opredelenie nukleotidnykh posledovatel'nostei dvukh genov leikotsitarnykh interferonov cheloveka.

Four different recombinant phages carrying interferon sequences were identified in the human gene bank on vector Charon 4A. A fragment of interferon A gene cloned previously through cDNA was used as a hybridization probe for analysis of the bank. The nucleotide sequence of DNA encoding the interferon genes was determined for 2 recombinant phages. One of these genes corresponded to the interferon A gene but one amino acid substitution (His 34-Arg). The second gene (I1) belonged to the family of the interferon C genes and differed from all the genes described earlier.

[Methods of sterilizing and preserving tendon transplants]. / Sposoby sterilizatsii sukhozhil'nykh transplantatov.

The authors describe three methods for making tendon transplants by using chemical sterilizing and preserving means having no unfavorable effect on their biological and plasty properties. The methods are simple, reliable and fairly suitable for a wide supply of clinical institutions with tendon transplants.

[Use of demineralized bone matrix in children]. / Primenenie demineralizovannogo kostnogo matriksa u detei.

Eighty five clinical observations of the authors have shown autotransplants demineralized in the solution of hydrochloric acid to possess pronounced osteoinductive properties. Their ability to induce osteogenesis was mostly pronounced in simultaneous plasty with a demineralized and frozen bone. Reconstructive processes are perfectly completed within 18-24 months after operation.

[Preparation and transplantation of demineralized bone tissue]. / Zagotovka i transplantatsiia demineralizovannoi kostnoi tkani.

The use of demineralized bone transplants is found to increase the effectiveness of allogenic transplantations of bone tissue due to its ability to induce active osteogenesis even when implanted intramuscularly. The method of preparing the bone transplants by demineralization in solutions of hydrochloric acid should be widely used in traumatology and orthopedy.

[Condition of interocortical connections in cranio-cerebral injuries with inferior parietal lobe lesions]. / Sostoianie mezhkorkovykh sviazei pri cherepno-mozovoi travme s porazheniem nizhnei temennoi doli.

The intercortical pathways and the clinical picture of the condition developing after an injury of the parietal lobe of the human brain were studied pathomorphologically (10 cases) and clinically (103 observations). It was shown that in cases of injury of the lower parietal region there developed a degeneration of the nervous fibres in various areas of the cortex of both the ipsi- and the contralateral hemisphere. Certain regularities of the distribution of the degenerated nervous fibres among the cortex areas were revealed, and their topics in various parts of a groove shown. The changes in the nervous conductors that maintain the intercortical connections reflect a structural reconstitution of the nervous elements and point to development of the pathological process that leads to functional disturbances and appearance of cortical symptoms which arise in craniocerebral injury and are characteristic for not only the lower parietal, but also for other divisions of the brain.