RESUMO
Data on the oxygen transport function of hemoglobin in patients with craniocerebral injury, cerebrovascular disorders, and epilepsy are presented. The role of 2,3-diphosphoglycerate contained in the erythrocytes, and of changes of the hemoglobin affinity to oxygen in the oxygenation of tissues in such patients is discussed. It is concluded that determinations of 2,3-diphosphoglycerate content in the erythrocytes be applied in clinical practice for diagnosing a number of nervous diseases accompanied by symptoms of cerebral hypoxia, so that the latter could be compensated in due time.
Assuntos
Encefalopatias/sangue , Ácidos Difosfoglicéricos/sangue , Oxiemoglobinas/metabolismo , Equilíbrio Ácido-Base , Adolescente , Adulto , Animais , Transfusão de Sangue , Lesões Encefálicas/sangue , Circulação Cerebrovascular , Transtornos Cerebrovasculares/sangue , Transtornos Cerebrovasculares/etiologia , Criança , Pré-Escolar , Epilepsia/sangue , Epilepsia/etiologia , Eritrócitos/análise , Eritrócitos/metabolismo , Glicólise , Haplorrinos , Humanos , Hipóxia Encefálica/sangue , Hipóxia Encefálica/complicações , Hipóxia Encefálica/terapia , Pessoa de Meia-Idade , Coelhos , Crânio/lesõesRESUMO
The authors have given a critical review of existing classifications of myodystrophies from 1884 till 1973. They propose a new systematization based on the formula of muscular lesions during different phases of the disease and on the formula of a generalization of the myodystrophical process. It is assumed that the formula of muscular atrophies and the direction of the generalization of the myodystrophical process is genetically conditioned and should be considered as an important sign of hereditary neuro-muscular diseases. The authors believe that the facio-scapulo-limb type of myodystrophy both clinically and genetically is not homogenous. This form of dystrophy should be divided into 2 variants: a gradually descending one and a descending one with a "jumping" of muscular atrophies from the upper half of the body (face, shoulder) to the peroneal group of muscles on the skin.