Assuntos
Eritrócitos/efeitos dos fármacos , Hemólise/efeitos dos fármacos , Lipossomos/farmacologia , Fosfatidiletanolaminas/farmacologia , Anemia Hemolítica/sangue , Animais , Bovinos , Eritrócitos/fisiologia , Cobaias , Hemoglobinúria Paroxística/sangue , Hemólise/fisiologia , Humanos , Técnicas In Vitro , Masculino , Ovinos , Medula Espinal , Extratos de Tecidos/farmacologiaAssuntos
Pancitopenia/etiologia , Pré-Leucemia/etiologia , Receptores Colinérgicos/fisiologia , Acetilcolinesterase/sangue , Animais , Diagnóstico Diferencial , Hematopoese/fisiologia , Humanos , Leucemia Experimental/diagnóstico , Leucemia Experimental/etiologia , Leucemia Experimental/terapia , Pancitopenia/diagnóstico , Pancitopenia/terapia , Pré-Leucemia/diagnóstico , Pré-Leucemia/terapiaRESUMO
The experiment on rats has shown that bone marrow coagulolytic properties were higher than those of the circulating blood. It is suggested that one of the mechanisms of bone marrow participation in the regulation of haemostasis is its ability to influence fibronectin and Ag VIII factor blood level.
Assuntos
Coagulação Sanguínea , Medula Óssea/fisiologia , Animais , Antígenos/análise , Células da Medula Óssea , Células Cultivadas , Fator VIII/imunologia , Fibrinólise , Fibronectinas/análise , Masculino , Ratos , Ratos Endogâmicos , Fatores de TempoRESUMO
Experiments were made on 10 dogs to study the influence of high cholinergic activity of the blood on protein of dog erythrocyte membranes. The cholinergic activity of the blood was enhanced by acetylcholine injections in a dose of 1 mg/kg and proserin injections in a dose of 0.008 mg/kg twice daily over a period of 2 to 7 months. It was found that the enhanced cholinergic activity of the blood entailed an increase insolubilization of erythrocyte membrane proteins and an appreciable build up (more than twofold) in the number of sulfhydryl groups, as well as a lowering (about twofold) of the number of disulfide groups in peripheral proteins of erythrocyte membranes.
Assuntos
Acetilcolina/farmacologia , Membrana Eritrocítica/análise , Eritrócitos/análise , Neostigmina/farmacologia , Peptídeos/análise , Animais , Fenômenos Químicos , Química , Cães , Humanos , Técnicas In Vitro , Proteínas de Membrana/análiseRESUMO
Experiments were carried out on 10 dogs to study the effect of high cholinergic activity of blood on the redox processes in membrane proteins of red blood cells. An increase in blood cholinergic activity was induced by parenteral injection of acetylcholine (0.9 mg/kg) and proserin (0.008 mg/kg) twice daily over 2 to 7 months. Long-term increase of blood cholinergic activity caused an elevation of solubilization of membrane proteins and redistribution of individual polypeptide from integral protein fractions into peripheral ones. The peripheral proteins manifested a pronounced increase in the number of sulfhydryl and reduction in disulfide groups. These data correlated with changes in the level of pyridine nucleotides in intact cells.
