RESUMO
Thirty three children with associative forms of thick-borne infection (thick-borne encephalitis with ixodic borreliosis) were clinically observed. The disease was characterized by subfebrile temperature, moderate intoxication, rare erythema (39.5%) and frequent cardiovascular disorders with development of Lyme carditis (32.6 +/- 7.2%) and further rise of hepatomegalia in the diseases dynamics and development of meningeal symptoms. There were observed changes in the cytokine spectrum, characterized by INF-gamma high levels, and hypersecretion of the whole spectrum cytokines in the dynamics, that provided the Th2 type immune response. High clinicoimmunological efficacy of the complex therapy with cycloferon as an immunomodulator providing more balanced production of pro- and anti-inflammatory cytokines (IL-1alpha, INF-gamma and IL-10) was shown.
Assuntos
Acridinas/uso terapêutico , Infecções por Borrelia/tratamento farmacológico , Infecções por Borrelia/etiologia , Encefalite Transmitida por Carrapatos/tratamento farmacológico , Encefalite Transmitida por Carrapatos/etiologia , Indutores de Interferon/uso terapêutico , Interferon gama/sangue , Adolescente , Infecções por Borrelia/sangue , Criança , Pré-Escolar , Citocinas/sangue , Encefalite Transmitida por Carrapatos/sangue , Febre/etiologia , Hepatomegalia , Humanos , Lactente , Interleucina-10/sangue , Interleucina-1alfa/sangue , Células Th2/efeitos dos fármacos , Células Th2/imunologiaRESUMO
Clinical options of infectious mononucleosis course depending on infecting agent etiology are presented for Epstein-Barr virus (EBV), cytomegalovirus (CMV), mono and mixed forms of the disease. Examined cytokine profiles demonstrate analogous changes of serum cytokines in the acute stage of the disease irrespective of etiological factors. Data show that it is important and useful clinically and immunologically to include immunomodulators--in particular, cycloferon--info a complex therapy of different types of mononucleosis.
Assuntos
Acridinas/uso terapêutico , Citocinas/sangue , Fatores Imunológicos/uso terapêutico , Imunoterapia/métodos , Mononucleose Infecciosa/tratamento farmacológico , Equilíbrio Th1-Th2/efeitos dos fármacos , Acridinas/administração & dosagem , Administração Oral , Antivirais/administração & dosagem , Estudos de Casos e Controles , Criança , Pré-Escolar , Coinfecção , Citocinas/imunologia , Citomegalovirus/efeitos dos fármacos , Citomegalovirus/imunologia , Feminino , Herpesvirus Humano 4/efeitos dos fármacos , Herpesvirus Humano 4/imunologia , Humanos , Fatores Imunológicos/administração & dosagem , Mononucleose Infecciosa/sangue , Mononucleose Infecciosa/imunologia , Mononucleose Infecciosa/fisiopatologia , Mononucleose Infecciosa/virologia , Masculino , Federação RussaRESUMO
The treatment of neurocirculatory asthenia and essential hypertension stage I and II with low-frequency bioresonance intracranial electrostimulation (BIES) performed on portable two-channel unit SEM-02 led to uneventful sthenic condition, relief of headache, improved sleep and performance, exercise tolerance. The quality of the bioenergetic field advanced in all the patients. Low-energy BIES may be used in many diseases, provides fast therapeutic effect in minimal intake of drugs, is nontoxic and hypoallergic. The unit SEM-02 proved 2.6 and 1.41 times more effective than similar domestic and foreign equipment, respectively.
