[Effect of acrylic acid and N-vinylpyrrolidone copolymer on delayed hypersensitivity to Staphylococcus aureus]. / Vliianie sopolimera akrilovoi kisloty i N-vinilpirrolidona na povyshennuiu chuvstvitel'nost' zamedlennogo tipa k Staphylococcus aureus.

The study made on the experimental models of delayed hypersensitivity (DH) to S. aureus strains Cowan-1 and Wood-46 has shown that acrylic acid/N-vinylpyrrolidone copolymers enhance the development of DH reactions at early periods of sensitization.

[Effect on helper activity of synthetic polyelectrolytes introduced into an in vitro system of interacting macrophages and thymus cells]. / Vliianie na khelpernuiu aktivnost' sinteticheskikh poliélektrolitov, vvedennykh v sistemu in vitro vzaimodeistvuiushchikh makrofagov i kletok timusa.

Our experiments have shown that the joint incubation of thymocytes and syngeneic macrophages in vitro for 60 minutes is accompanied by a certain increase in the helper activity of thymocytes. The presence of polyacrylic acid or the copolymer of acrylic acid and N-vinyl-pyrrolidone, containing 56 mol% of acrylic acid, in this system ensures a considerable increase in the helper activity of thymocytes, incubated jointly with marrow cells and sheep red blood cells and then transferred into a cell culture in vivo.

[Effect of copolymers of N-vinylpyrrolidone and acrylic acid on individual stages of immunogenesis]. / Vliianie sopolimerov N-vinilpirrolidona i akrilovoi kisloty na otdel'nye étapy immunogeneza.

The analysis of NA-5 and NA-6, copolymers of acrylic acid and N-vinylpyrrolidone obtained by the method of radical copolymerization, indicated that these copolymers, while having no toxicity characteristic of polyacrylic acid known to be a powerful agent for stimulating immunogenesis, increased the migration of stem cells, and the processes of T and B lymphocyte spreading, as well as sharply enhanced the effect of interaction between T and B lymphocytes and partially replaced the helper function of T cells; all these actions finally enhanced immune response in the body. A decrease in the toxicity of copolymers was found to be in linear relationship with the percentage of the links of acrylic acid, whereas the adjuvant activity of the copolymers remained unchanged.