[Enterovirus infections and meningitis in children].

OBJECTIVE: To compare clinical characteristics in children with enterovirus infections (EVI) and meningitis with detailed characteristics of the changes in the content of cerebrospinal fluid (CSF) confirmed in the laboratory. MATERIAL AND METHODS: The results of examinations of 97 children, aged from 2.5 to 15 years, 3 adolescents and 1 adult female patient with EVI were analyzed. Enterovirus RNA isolation and detection in feces and CSF was performed using PCR. RESULTS AND CONCLUSION: Enterovirus RNA in CSF was detected in 44 children, including 3 patients with cytosis (5-7-19 cells in 3 mm3). The frequency and severity of symptoms in 42 patients with EVI and meningitis, 14 children with EVI without meningitis and 8 patients with ICD-10 «Meningitis unspecified¼ are presented. The initial CSF pleocytosis in 1-3 day (4-5 day for two-wave course) in EVI and meningitis was <100 in 4, from 100 to 1000 in 33, >1000 (max 3036) cells in 3 mm3 in 5 patients, including 15 with the predominance of neutrophils (from 77 to 97% in cytosis 114-2300 cells in 3 mm(3)). In the peripheral blood, leukocytosis 10.9-13.8×10(9)/л was noted in 12 children and leukocytosis 14.4-18.7×10(9)/л with the «left shift¼ in 7. Most of the children (n=37) with EVI and meningitis were discharged from the hospital within 10-17 days. The authors suggest the importance of including the variety of clinical presentations of EVI in the additional item «B10 Enterovirus infections¼ in upcoming ICD-11.

[Brain and spine cord lesions caused by syphilis].

OBJECTIVE: To analyze clinical features of the nervous system damage in syphilis taking into account the changes in the content of cerebrospinal fluid and clinical/anatomical brain damages of the brain. METHODS: The study was based on the analysis of 47 case histories of patients hospitalized in 1995-2001. The group included 47 patients, aged from 17 to 60 years. RESULTS: Syphilitic meningitis, syphilitic meningoneuritis, syphilitic menongoencephalitis, syphilitic meningovasculitis, cerebral gummas, syphilitic meningomyelitis and mental changes caused by syphilis are reviewed. CONCLUSIONS: The pathogenesis of different clinical forms of syphilitic damages of the brain and terminological issues are discussed.

[Indices of cellular immunity in patients with influenza A1]. / Pokazateli kletochnogo immuniteta u bol'nykh grippom A1.

The content of T-lymphocytes was determined by the method of spontaneous rosette formation according to Bach et al. and of B-lympocytes by the method of complementary rosette formation according to Mendes et al. in patients with uncomplicated and complicated influenza A1. In the acute period the values of T-lymphocytes were low and of B-lymphocytes and "O" cells high. During the convalescent period the amount of T-lymphocytes became normal in most patients. In patients with concurrent chronic diseases and in elderly patients the amount of T-lymphocytes remained low for a longer period and did not become normal in most of them during convalescence. The amount of B-lymphocytes at the time of recovery remained high, but in patients with complicated forms of the diseases the values were higher.