RESUMO
El dolor abdominal es uno de los síntomas peor tolerados por los pacientes con síndrome del intestino irritable (SII). Estudios realizados los últimos años sugieren que existe una disbiosis intestinal en estos pacientes, que podría ser responsable, al menos en parte, de los síntomas. La revisión de la literatura apunta hacia que los probióticos podrían ser una terapia efectiva en el alivio del dolor en el SII, y se acepta que sus efectos son específicos de cuerdo a la cepa empleada. En este artículo se revisa el efecto que cada cepa, o mezcla de probióticos, tiene en el alivio del dolor abdominal, según los ensayos clínicos publicados, y se discuten los posibles mecanismos de acción. Se proponen nuevas perspectivas de investigación para poder dilucidar el mecanismo de acción de los probióticos en el alivio del dolor abdominal en estos pacientes.
Abdominal pain is one of the least well tolerated symptoms in patients with irritable bowel syndrome (IBS). Studies conducted in recent years suggest that dysbiosis in these patients may be responsible, at least in part, for these symptoms. This literature review indicates that probiotics may be an effective therapy for the relief of pain in patients with IBS and recognizes that the effects of probiotics are specific to the strain used. In this article we review the effect that each strain or mixture of probiotics has for relieving abdominal pain according to published clinical trials and we also discuss possible mechanisms of action. New perspectives are proposed for research to elucidate the mechanisms of probiotic action for relief of abdominal pain in these patients.
Assuntos
Humanos , Dor Abdominal , Síndrome do Intestino Irritável , ProbióticosRESUMO
INTRODUCTION: Few data document the use of complementary and alternative medicine (CAM) in Europe, with even fewer investigating use by children. METHODS: A narrative, non-systematic review of CAM use in Europe was performed by combining data from published surveys with expert perspectives. Limitations created by a lack of representative studies, varying definitions of CAM use, and what qualifies as CAM in different countries was partially overcome by integrating local experts to summarise information available only in the national language and provide their perspectives about CAM availability, quality, use and popularity in their countries using a semi-structured questionnaire. Local and international published surveys were summarised, and the prevalence of CAM use was extrapolated. RESULTS: Data from 20 European countries were available, representing 69% of the European population. Some data about CAM use by the general population were available for 90% of the examined countries, whereas peer-reviewed published surveys were available for only 60%. We extrapolated that 56% (range: 10-90%, adjusted for population size) of the European population in general had used CAM at least once in the past year. Surveys in CAM use by children were available for 55% of the investigated countries. The extrapolated prevalence of CAM use by children in Europe was 52% (range: 5-90%, adjusted for population size). Paediatric CAM experts reported an increasing awareness for and use of CAM in healthcare institutions. CONCLUSION: This precursor for further surveys indicates that CAM appears to be popular not only among adults in Europe, but also for children. Development of a pan-European definition of CAM use and CAM therapies are required to achieve surveys comparable between European countries. Additionally, more research investigating the efficacy and potential adverse effects of CAM therapies is needed because of increasing CAM use by children in Europe.
Assuntos
Terapias Complementares/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde , Fatores Etários , Conscientização , Criança , Europa (Continente) , Pesquisas sobre Atenção à Saúde , Humanos , PediatriaRESUMO
Desde hace años, el cáncer de pulmón es el tumor que origina un mayor número de muertes en los países industrializados y emergentes. Un cuidado meticuloso de los aspectos nutricionales, insistiendo en altos niveles de consumo de frutas y verduras, puede suponer un importante elemento de prevención primaria. Investigando el efecto de sustancias con poder antioxidante, numerosos estudios epidemiológicos han centrado su atención en los flavonoides. El objetivo de esta revisión es analizar la evidencia científica disponible en la literatura médica respecto al papel de los flavonoides en el cáncer de pulmón. Tras una revisión bibliográfica sistemática, se identificaron un metaanálisis, una revisión sistemática, 11 estudios prospectivos de cohortes y 5 estudios de casos y controles.Tras analizar la evidencia científica establecida por estos trabajos, se observó un pequeño efecto protector del consumo de flavonoides (especialmente a altas dosis) frente al desarrollo de cáncer de pulmón, aunque no todos los estudios lo confirman. En este sentido, parecen no existir diferencias entre la ingesta selectiva de distintos tipos de flavonoides y el consumo de flavonoides totales, pero sí se observan diferencias entre las distintas poblaciones estudiadas (AU)
For years, lung cancer has been the tumor causing more deaths in industrialized and emerging countries. A meticulous care of the nutritional aspects, with emphasis on high consumption of fruits and vegetables, can be an important element of primary prevention.Taking into account research on the effect of substances with antioxidant power, many epidemiological studies have focused on flavonoids. The objective of this review is to analyze the available scientific evidence in the literature regarding the role of flavonoids in lung cancer.After a systematic literature review, we identified a meta-analysis, a systematic review, 11 prospective cohort studies and 5 case-control studies. After reviewing the scientific evidence provided by these works, there was a small protective effect of flavonoid consumption (especially at high doses) against the development of lung cancer, although not all studies confirmed it. There seems to be no differences between selective intake of different types of flavonoids and consumption of total flavonoids, but there are differences between the different populations studied (AU)
Assuntos
Humanos , Flavonoides/farmacocinética , Neoplasias Pulmonares/prevenção & controle , Frutas , Verduras , Antioxidantes/farmacocinética , Prevenção Primária/métodosRESUMO
Desde hace años, el cáncer de pulmón es el tumor que origina un mayor número de muertes en los países industrializados y emergentes. Un cuidado meticuloso de los aspectos nutricionales, insistiendo en altos niveles de consumo de frutas y verduras, puede suponer un importante elemento de prevención primaria. Investigando el efecto de sustancias con poder antioxidante, numerosos estudios epidemiológicos han centrado su atención en los flavonoides. El objetivo de esta revisión es analizar la evidencia científica disponible en la literatura médica respecto al papel de los flavonoides en el cáncer de pulmón. Tras una revisión bibliográfica sistemática, se identificaron un metaanálisis, una revisión sistemática, 11 estudios prospectivos de cohortes y 5 estudios de casos y controles. Tras analizar la evidencia científica establecida por estos trabajos, se observó un pequeño efecto protector del consumo de flavonoides (especialmente a altas dosis) frente al desarrollo de cáncer de pulmón, aunque no todos los estudios lo confirman. En este sentido, parecen no existir diferencias entre la ingesta selectiva de distintos tipos de flavonoides y el consumo de flavonoides totales, pero sí se observan diferencias entre las distintas poblaciones estudiadas (AU)
No disponible
Assuntos
Humanos , Flavonoides/farmacocinética , Neoplasias Pulmonares/prevenção & controle , Frutas , Verduras , Antioxidantes/farmacocinética , Prevenção Primária/métodosRESUMO
For years, lung cancer has been the tumor causing more deaths in industrialized and emerging countries. A meticulous care of the nutritional aspects, with emphasis on high consumption of fruits and vegetables, can be an important element of primary prevention. Taking into account research on the effect of substances with antioxidant power, many epidemiological studies have focused on flavonoids. The objective of this review is to analyze the available scientific evidence in the literature regarding the role of flavonoids in lung cancer. After a systematic literature review, we identified a meta-analysis, a systematic review, 11 prospective cohort studies and 5 case-control studies. After reviewing the scientific evidence provided by these works, there was a small protective effect of flavonoid consumption (especially at high doses) against the development of lung cancer, although not all studies confirmed it. There seems to be no differences between selective intake of different types of flavonoids and consumption of total flavonoids, but there are differences between the different populations studied.
