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1.
Photochem Photobiol Sci ; 22(11): 2651-2673, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37733213

RESUMO

This study focuses on the molecular design and synthesis of salt spiropyrans with near-IR fluorescence. The structure of the obtained compounds was confirmed by NMR, IR and mass spectroscopy. In the course of studying the spectral and photoluminescent characteristics, it was possible to reveal the effect of some substituents in various positions on the properties of spiropyran dyes. Due to the structural similarity of one of the isomers to cyanine dyes, the obtained compounds are of interest as potential fluorescent probes for bioimagimg, in particular, for DNA studies. To reveal their ability of binding to DNA molecules molecular docking was carried out. Toxic effects of compounds demonstrating NIR fluorescence were studied on biofilms, as well as using bacterial lux-biosensors.


Assuntos
Benzopiranos , Corantes Fluorescentes , Simulação de Acoplamento Molecular , Benzopiranos/química , Corantes Fluorescentes/química , DNA
2.
Chem Biodivers ; 16(1): e1800490, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30382617

RESUMO

The approach to the novel 1-[(2-aminoethyl)sulfonyl]-2-arylpyrrolidines via unique intramolecular cyclization/aza-Michael reactions of N-(4,4-diethoxybutyl)ethenesulfonamide have been developed, which benefits from high yields of target compounds, mild reaction conditions, usage of inexpensive and low-toxic reagents, and allows for wide variability in both amine and aryl moieties. Biotesting with whole-cell luminescent bacterial biosensors responding to DNA damage showed that all tested compounds are not genotoxic. Tested compounds differently affect the formation of biofilms by Vibrio aquamarinus DSM 26054. Some of the tested compounds were found to suppress the bacterial biofilms growth and thus are promising candidates for further studies.


Assuntos
Antibacterianos/síntese química , Antibacterianos/farmacologia , Biofilmes/efeitos dos fármacos , Pirrolidinas/síntese química , Pirrolidinas/farmacologia , Vibrio/efeitos dos fármacos , Antibacterianos/química , Biomassa , Dano ao DNA , Pirrolidinas/química , Solubilidade , Análise Espectral/métodos , Vibrio/genética , Vibrio/crescimento & desenvolvimento , Vibrio/metabolismo , Água/química
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