RESUMO
Current methods do not provide a way always to distinguish benign from malignant gastrointestinal smooth-muscle tumors. We compared immunocytochemical assessment of proliferating-cell nuclear antigen expression with flow cytometry and mitotic figure-counting as a prognostic marker in 85 gastrointestinal smooth-muscle tumors. Although proliferating-cell nuclear antigen expression was associated with poor prognosis in univariate statistical analysis, it was not significant in multivariate proportional hazards models that included either the mitotic index or aneuploidy of the flow-cytometric G2M peak. We conclude that proliferating cell nuclear antigen assessment is not warranted in the routine evaluation of gastrointestinal smooth-muscle tumors.
Assuntos
Neoplasias Gastrointestinais/patologia , Leiomiossarcoma/patologia , Músculo Liso/patologia , Antígeno Nuclear de Célula em Proliferação/análise , Biomarcadores Tumorais , Citometria de Fluxo , Neoplasias Gastrointestinais/química , Humanos , Técnicas Imunoenzimáticas , Leiomiossarcoma/química , Índice Mitótico , Análise Multivariada , Músculo Liso/química , Prognóstico , Análise de SobrevidaRESUMO
Hemangiomas of the mediastinum are rare tumors. Fewer than 100 have been reported. This study reviews the cases of 15 patients with mediastinal hemangiomas confirmed pathologically. We analyzed and evaluated the presentation, evaluation, and treatment. Follow-up is available for 14 of the 15 patients and ranges from 15 months to 15 years. Eight of the 15 patients were seen with signs and symptoms related to the tumor. This presentation correlated with invasion of contiguous mediastinal structures by the tumor. Six patients underwent total excision and 6, subtotal excision. During follow-up, residual tumor did not spread, become symptomatic, or show evidence of malignant degeneration. Based on this analysis, we believe that in patients in whom total excision of this tumor can be accomplished only by hazardous resection, a subtotal resection should be performed.