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1.
Radiat Prot Dosimetry ; 122(1-4): 362-6, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17151013

RESUMO

Human exposure to space radiation implies two kinds of risk, both stochastic and deterministic. Shielding optimisation therefore represents a crucial goal for long-term missions, especially in deep space. In this context, the use of radiation transport codes coupled with anthropomorphic phantoms allows to simulate typical radiation exposures for astronauts behind different shielding, and to calculate doses to different organs. In this work, the FLUKA Monte Carlo code and two phantoms, a mathematical model and a voxel model, were used, taking the Galactic Cosmic Rays (GCR) spectra from the model of Badhwar and O'Neill. The time integral spectral proton fluence of the August 1972 Solar Particle Event (SPE) was represented by an exponential function. For each aluminium shield thickness, besides total doses the contributions from primary and secondary particles for different organs and tissues were calculated separately. More specifically, organ-averaged absorbed doses, dose equivalents and a form of 'biological dose', defined on the basis of initial (clustered) DNA damage, were calculated. As expected, the SPE doses dramatically decreased with increasing shielding, and doses in internal organs were lower than in skin. The contribution of secondary particles to SPE doses was almost negligible; however it is of note that, at high shielding (10 g cm(-2)), most of the secondaries are neutrons. GCR organ doses remained roughly constant with increasing Al shielding. In contrast to SPE results, for the case of cosmic rays, secondary particles accounted for a significant fraction of the total dose.


Assuntos
Radiação Cósmica/efeitos adversos , Exposição Ambiental/efeitos adversos , Exposição Ambiental/análise , Modelos Biológicos , Lesões por Radiação/etiologia , Lesões por Radiação/prevenção & controle , Proteção Radiológica/métodos , Astronautas , Simulação por Computador , Relação Dose-Resposta à Radiação , Humanos , Doses de Radiação , Proteção Radiológica/instrumentação , Radiação Ionizante , Medição de Risco/métodos , Fatores de Risco
2.
Adv Space Res ; 35(2): 214-22, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15934197

RESUMO

The modeling of ion transport and interactions in matter is a subject of growing interest, driven by the continuous increase of possible application fields. These include hadron therapy, dosimetry, and space missions, but there are also several issues involving fundamental research, accelerator physics, and cosmic ray physics, where a reliable description of heavy ion induced cascades is important. In the present work, the capabilities of the FLUKA code for ion beams will be briefly recalled and some recent developments presented. Applications of the code to the simulation of therapeutic carbon, nitrogen and oxygen ion beams, and of iron beams, which are of direct interest for space mission related experiments, will be also presented together with interesting consideration relative to the evaluation of dosimetric quantities. Both applications involve ion beams in the AGeV range.


Assuntos
Simulação por Computador , Radiação Cósmica , Modelos Teóricos , Radioterapia , Carbono , Íons , Ferro , Transferência Linear de Energia , Método de Monte Carlo , Aceleradores de Partículas , Imagens de Fantasmas , Polimetil Metacrilato , Doses de Radiação , Monitoramento de Radiação/instrumentação , Voo Espacial
3.
Adv Space Res ; 34(6): 1338-46, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15881774

RESUMO

Distributions of absorbed dose and DNA clustered damage yields in various organs and tissues following the October 1989 solar particle event (SPE) were calculated by coupling the FLUKA Monte Carlo transport code with two anthropomorphic phantoms (a mathematical model and a voxel model), with the main aim of quantifying the role of the shielding features in modulating organ doses. The phantoms, which were assumed to be in deep space, were inserted into a shielding box of variable thickness and material and were irradiated with the proton spectra of the October 1989 event. Average numbers of DNA lesions per cell in different organs were calculated by adopting a technique already tested in previous works, consisting of integrating into "condensed-history" Monte Carlo transport codes--such as FLUKA--yields of radiobiological damage, either calculated with "event-by-event" track structure simulations, or taken from experimental works available in the literature. More specifically, the yields of "Complex Lesions" (or "CL", defined and calculated as a clustered DNA damage in a previous work) per unit dose and DNA mass (CL Gy-1 Da-1) due to the various beam components, including those derived from nuclear interactions with the shielding and the human body, were integrated in FLUKA. This provided spatial distributions of CL/cell yields in different organs, as well as distributions of absorbed doses. The contributions of primary protons and secondary hadrons were calculated separately, and the simulations were repeated for values of Al shielding thickness ranging between 1 and 20 g/cm2. Slight differences were found between the two phantom types. Skin and eye lenses were found to receive larger doses with respect to internal organs; however, shielding was more effective for skin and lenses. Secondary particles arising from nuclear interactions were found to have a minor role, although their relative contribution was found to be larger for the Complex Lesions than for the absorbed dose, due to their higher LET and thus higher biological effectiveness.


Assuntos
DNA/efeitos da radiação , Modelos Teóricos , Imagens de Fantasmas , Proteção Radiológica , Atividade Solar , Astronautas , Dano ao DNA , Relação Dose-Resposta à Radiação , Humanos , Cristalino/efeitos da radiação , Modelos Anatômicos , Método de Monte Carlo , Doses de Radiação , Eficiência Biológica Relativa , Pele/efeitos da radiação , Vísceras/efeitos da radiação
4.
Radiat Prot Dosimetry ; 103(1): 19-28, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12596985

RESUMO

The action of neutron fields on biological structures was investigated on the basis of chromosome aberration induction in human cells. Available experimental data on aberration induction by neutrons and their interaction products were reviewed. Present criteria adopted in neutron radiation protection were discussed. The linear coefficient alpha and the quadratic coefficient beta describing dose-response curves for dicentric chromosomes induced by neutrons of different energies were calculated via integration of experimental data on dicentric induction by photons and charged particles into the Monte Carlo transport code FLUKA. The predicted values of the linear coefficients for neutron beams of different energies showed good agreement with the corresponding experimental values, whereas the data themselves indicated that the neutron quadratic coefficient cannot be obtained by 'averaging' the beta values of recoil ions and other nuclear reaction products. This supports the hypothesis that neutron induced aberrations increase substantially linearly with dose, a question that has been object of debate for a long time and is still open.


Assuntos
Aberrações Cromossômicas , Cromossomos Humanos/efeitos da radiação , Nêutrons/efeitos adversos , Relação Dose-Resposta à Radiação , Nêutrons Rápidos/efeitos adversos , Raios gama/efeitos adversos , Humanos , Transferência Linear de Energia , Método de Monte Carlo , Imagens de Fantasmas , Proteção Radiológica , Radiometria/instrumentação , Eficiência Biológica Relativa , Água , Raios X/efeitos adversos
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