Use of intra-osseous access in adults: a systematic review.

BACKGROUND: Indications for intra-osseous (IO) infusion are increasing in adults requiring administration of fluids and medications during initial resuscitation. However, this route is rarely used nowadays due to a lack of knowledge and training. We reviewed the current evidence for its use in adults requiring resuscitative procedures, the contraindications of the technique, and modalities for catheter implementation and skill acquisition. METHODS: A PubMed search for all articles published up to December 2015 was performed by using the terms "Intra-osseous" AND "Adult". Additional articles were included by using the "related citations" feature of PubMed or checking references of selected articles. Editorials, comments and case reports were excluded. Abstracts of all the articles that the search yielded were independently screened for eligibility by two authors and included in the analysis after mutual consensus. In total, 84 full-text articles were reviewed and 49 of these were useful for answering the following question "when, how, and for which population should an IO infusion be used in adults" were selected to prepare independent drafts. Once this step had been completed, all authors met, reviewed the drafts together, resolved disagreements by consensus with all the authors, and decided on the final version. RESULTS: IO infusion should be implemented in all critical situations when peripheral venous access is not easily obtainable. Contraindications are few and complications are uncommon, most of the time bound to prolonged use. The IO infusion allows for blood sampling and administration of virtually all types of fluids and medications including vasopressors, with a bioavailability close to the intravenous route. Unfortunately, IO infusion remains underused in adults even though learning the technique is rapid and easy. CONCLUSIONS: Indications for IO infusion use in adults requiring urgent parenteral access and having difficult intravenous access are increasing. Physicians working in emergency departments or intensive care units should learn the procedures for catheter insertion and maintenance, the contraindications of the technique, and the possibilities this access offers.

Biomechanical study of dynamic changes in L4-L5 foramen surface area in flexion and extension after implantation of four interspinous process devices.

BACKGROUND: Lumbar spinal stenosis is a major public health issue. Interspinous devices implanted using minimally invasive techniques may constitute an alternative to the reference standard of bony decompression with or without intervertebral fusion. However, their indications remain unclear, due to a paucity of clinical and biomechanical data. Our objective was to evaluate the effects of four interspinous process devices implanted at L4-L5 on the intervertebral foramen surface areas at the treated and adjacent levels, in flexion and in extension. MATERIALS AND METHOD: Six fresh frozen human cadaver lumbar spines (L2-sacrum) were tested on a dedicated spinal loading frame, in flexion and extension, from 0 to 10 N·m, after preparation and marking of the L3-L4, L4-L5, and L5-S1 foramina. Stereoscopic 3D images were acquired at baseline then after implantation at L4-L5 of each of the four devices (Inspace(®), Synthes; X-Stop(®), Medtronic; Wallis(®), Zimmer; and Diam(®), Medtronic). The surface areas of the three foramina of interest were computed. RESULTS: All four devices significantly opened the L4-L5 foramen in extension. The effects in flexion separated the devices into two categories. With the two devices characterized by fixation in the spinous processes (Wallis(®) and Diam(®)), the L4-L5 foramen opened only in extension; whereas with the other two devices (X-Stop(®) and Inspace(®)), the L4-L5 foramen opened not only in extension, but also in flexion and in the neutral position. None of the devices implanted at L4-L5 modified the size of the L3-L4 foramen. X-Stop(®) and Diam(®) closed the L5-S1 foramen in extension, whereas the other two devices had no effect at this level. CONCLUSION: Our results demonstrate that interspinous process devices modify the surface area of the interspinous foramina in vitro. Clinical studies are needed to clarify patient selection criteria for interspinous process device implantation. LEVEL OF EVIDENCE: Level IV. Investigating an orthopaedic device.

Mechanistic analysis of nonoxygenated hypothermic machine perfusion's protection on warm ischemic kidney uncovers greater eNOS phosphorylation and vasodilation.

Protection of endothelial cell function may explain the benefits of nonoxygenated hypothermic machine perfusion (MP) for marginal kidney preservation. However, this hypothesis remains to be tested with a preclinical model. We postulated that MP protects the nitric oxide (NO) signaling pathway, altered by static cold storage (CS), and improves renal circulation recovery compared to CS. The endothelium releases the vasodilator NO in response to flow via either increased endothelial NO synthase (eNOS) expression (KLF2-dependent) or activation of eNOS by phosphorylation (via Akt, PKA or AMPK). Using a porcine model of kidney transplantation, including 1 h of warm ischemia and preserved 24 h by CS or MP (n=5), we reported that MP did not alter the cortical levels of KLF2 and eNOS at the end of preservation, but significantly increased eNOS activating phosphorylation compared to CS. eNOS phosphorylation appeared AMPK-dependent and was concomitant to an increased NO-dependent vasodilation of renal arteries measured, ex situ, at the end of preservation. In vivo, laser Doppler showed that cortical microcirculation was improved at reperfusion in MP kidneys. In conclusion, we demonstrate for the first time, in a large-animal model, that MP protects the NO signaling pathway, confirming the value of MP for marginal kidney preservation.

[Value of simulation in pediatrics]. / Intérêt de la simulation en pédiatrie.

The authors present the concepts of simulation and its utilization in pediatrics. Simulation in medicine is a teaching method that has not yet been developed in Europe and has not spread in pediatrics in France. Motivations for simulation are first and foremost ethical: "Never the first time on patients!" Simulation also provides benefits in teaching communication skills and theoretical concepts. It is an essential means to maintain patient safety by limiting the risk of errors. It covers teaching procedures requiring realistic models such as in teaching communication and crisis resource management. Simulation can also be used for teaching disclosure of bad news, using actors. Simulation skills are acquired during debriefing, when the supervisor acts as a facilitator. Evaluation is mandatory in simulation, dependent on the how realistic the models are and on the performance of a procedure or multidisciplinary team management. Performance can be objectively assessed only with validated tools. Simulation will become a mandatory teaching method in medicine.

Tuberoplasty: minimally invasive osteosynthesis technique for tibial plateau fractures.

Fractures of the tibial plateau are in constant progression. They affect an elderly population suffering from a number of comorbidities, but also a young population increasingly practicing high-risk sports and using two-wheeled vehicles. The objective of this study was therefore to propose a new technique for the treatment of this type of fracture. There are a variety of classical pitfalls of conservative treatment such as defective reduction resulting in early osteoarthritis and alignment defects. Conventional treatments lead to joint stiffness and amyotrophy of the quadriceps, caused by the open technique and late loading. We propose an osteosynthesis technique for tibial plateau fractures with minimally invasive surgery. A minimally invasive technique would be more appropriate to remedy all of the surgical drawbacks resulting from current practices. The surgical technique that we propose uses a balloon allowing progressive and total reduction, associated with percutaneous screw fixation and filling with polymethylmethacrylate (PMMA) cement. The advantages are optimal reduction, minimal devascularization, soft tissues kept intact, as well as early loading and mobilization. This simple technique seems to be a good alternative to conventional treatment. The most comminuted fractures as well as the most posterior compressions can be treated, while causing the least impairment possible. Arthroscopy can be used to verify fracture reduction and cement leakage. At the same time, it can be used to assess the associated meniscal lesions and to repair them if necessary.

[The anatomical substrate of muscle contractility]. / Le support anatomique de la contraction musculaire.

Muscle fiber action participates in a true contractile machinery associated with noncontractile components providing mechanical stability. The myofibril, the muscle fiber subentity, has an extremely consistent architecture, composed of longitudinal cylindrical units called sarcomeres, the skeletal muscle length functional unit, a highly important place in the transduction of chemical signal into mechanical contractile energy, for the most part mediated by calcium. The sarcoplasmic reticulum is the other major component of muscle fiber and is dedicated to calcium storage, liberation and distribution to the fiber, under the influence of action potential propagation. This phenomenon is called excitation-contraction coupling. This paper explores muscle anatomy from its main embryologic stages of development to its histochemical specificity, including its molecular constitution, and details the main morphofunctional relations supporting muscle contraction.

Abnormalities of the gallbladder, clinical effects.

The aim of this review of the literature was to present and discuss the anatomical and embryological basis of congenital abnormalities of the gallbladder, based on a case of volvulus. In the rare cases of ectopic gallbladder, diagnosis of a biliary disease could be difficult. In such cases surgery can also be dangerous, especially when it is associated with abnormalities of the intra-hepatic biliary and vascular tree. This study, based on the embryology of the extra hepatic bile duct, focused on the most frequent gallbladder abnormalities to keep them in mind.

Anatomical pitfalls in the technique for total extra peritoneal laparoscopic repair for inguinal hernias.

PURPOSE: The totally extraperitoneal laparoscopic approach for the treatment of inguinal hernia is a well-recognized technique with proven efficacy, low failure rate, and reduced post-operative pain. This laparoscopic technique is reputed to be a more difficult procedure to learn and practice than a laparoscopic trans-abdomino-pre-peritoneal procedure: we hope this is because many surgeons don't well know extra-peritoneal anatomy of groin. So we proposed a "step by step" anatomical analysis, with pitfalls to avoid, of a totally extraperitoneal laparoscopic approach for treatment of inguinal hernia. METHODS: Our experience with totally extraperitoneal laparoscopic inguinal hernia repair with regard to the morphology of the inguinal-femoral region concerns 23 cadaver dissection and more than 400 surgical procedures, now permits clarification of a surgical technique that has hitherto not been well known. CONCLUSION: Photographic representations of surgical views are displayed, and detailed descriptions applicable to anatomical structures are presented.

[A new method for radio-carpal joint injection]. / Une nouvelle technique de ponction de l'articulation radio-carpienne.

OBJECTIVE: Previous techniques for radiocarpal joint injection introduce the needle directly between the navicular and the radius. We propose here a new technique using the same puncture site for midcarpal and radiocarpal arthrograms without need for needle reinsertion. MATERIALS AND METHODS: A prospective study of 85 radiocarpal injections for arthrography was performed. For each case, the needle tip was positioned at the medial part of the proximal scaphoid, under the mid carpal joint, and directed obliquely with a 45 degrees angle to the joint space to reach the radiocarpal joint. In case of midcarpal and radiocarpal arthrograms, a single puncture site was always used. RESULTS: Injection of the radiocarpal joint was successful in 82 of the 82 cases. CONCLUSION: The method proposed here is simple, efficient and uses a single site of puncture in cases requiring bi-compartmental injections.

A three-dimensional model of the shoulder girdle. Forces developed in deltoid and supraspinatus muscles during abduction.

The aim of this study was to design a three-dimensional model of the human shoulder girdle. Fourteen muscles were modelled geometrically using robotics software (Solid Dynamics System). A static study in reverse dynamics allowed the forces developed in seven muscles to be studied, particularly in the deltoid and supraspinatus during abduction of the arm with the forearm bent at 90 degrees, the scapula being fixed. After optimization by Excel, this model allowed simultaneous curves of forces developed in every modelled muscular bundle to be obtained during various degrees of abduction of the arm from 0 degrees to 100 degrees, in the scapular plane. The analysis of supraspinatus and deltoid curves revealed an interesting chronology of action. The first muscle developed efforts estimated at 140 N, quickly relieved by the deltoid. It is also interesting to note that a constant action of supraspinatus was found throughout abduction of the arm. Clinical applications seem to be in simulation of muscular pathology of the shoulder girdle. This study is continuing by releasing the fixed scapula and by simulating muscle transfers proposed for massive ruptures of the rotator cuff.

The pectineal ligament: anatomical study and surgical applications.

The aim of this study was to reinforce the importance of the pectineal ligament in laparoscopic surgery for groin hernia and female urinary incontinence, particularly its anatomical importance in the myopectineal region. A morphologic study was conducted on 44 pectineal ligaments from 23 embalmed and one fresh human cadavers, together with a radiological study on four volunteer patients. Anatomical and histological findings confirm the fact that the ligament of Cooper represents a thickening of the pectineal fascia rather than a thickening from the periosteum. The pectineal ligament provides a landmark in each approach, open or laparoscopic, anterior or posterior surgery.

A prospective radiological anatomical study of the variations of the position of the colon in the left pararenal space.

Percutaneous puncture of the kidney allows direct access to the pyelocalicial cavities. The posterior approach of this retroperitoneal organ can be complicated of transcolic punctures due to the postrenal position of the colon. A prospective radiological anatomical study of the relationship between the left kidney and the descending colon was undertaken. One hundred computed tomograms of adult subjects were obtained from which the anatomy of the left perirenal area was determined: the descending colon is more frequently behind the kidney in the young females. Two main factors determinants of this situation are: 1) colon ontogenesis in relation to the attachment of the primitive mesocolon, permitting a 'fixed' left colon, or 'moving' left colon at the end of a long mesocolon, allowing it to pass behind the kidney; 2) a mechanical factor whereby the accumulation of perirenal fat with increasing age may be a limiting factor in lateral displacement of the colon.

[Prospective study on admissions for iatrogenic adverse effects in the emergency service of hospital university center in Poitiers]. / Enquête prospective sur les admissions pour iatrogénie médicamenteuse dans le service d'accueil des urgences du centre hospitalier universitaire de Poitiers.

Hospital admissions resulting from an adverse drug reaction have been studied in the emergency unit of the university hospital in Poitiers during a 27-day period. This prospective study consisted in documenting all observations considered as an ADR by the medical practitioner in charge of the patient. There were 1235 hospital admissions to the emergency unit during the study period. Thirty-one (2.5 per cent) of admissions were considered to be drug-related. Women were more often affected than men. Patients with ADR were classified taking into account the type of pathology and the drug responsible for the effect. Dermatological and gastrointestinal reactions were predominant. Antibiotic and analgesic drugs were the most common drug groups implicated in causing an ADR.

[Datura stramonium poisoning: the diagnosis is clinical, treatment is symptomatic]. / Intoxication par Datura stramonium: le diagnostic est clinique, le traitement est symptomatique.

Datura stramonium is a hallucinogenic plant found in urban or rural areas. It contains three main toxic alkaloids: atropine, scopolamine, and hyosciamine. Consumption of any part of the plant can result in severe anticholinergic toxicity. Clinical symptoms are those seen in atropine poisoning, particularly hallucinations and mydriasis. Prognostic is good in this study. Patients always require hospitalisation because of agitated behavior. Symptomatic treatment is efficient. Clinicians should be aware of the potential abuse of botanicals such as jimson weed to avoid excessive investigations.

[Appendix in a left crural herniated position: apropos of a case. Explanation by human ontogenesis]. / Appendice en situation herniaire crurale gauche: à propos d'un cas. Explication par l'ontogenèse humaine.

The authors report about one case of left crural strangulation containing the appendix. The right flexure of the colon is fixed in its usual infrahepatic position. The ascending colon, on the other hand, floats, and the cecum is in a left iliac position. An ontogenic explanation is proposed, on the basis of recent anatomical work, and compared with traditional hypotheses about the evolution of the gastrointestinal tract in relation to the development of the peritoneum.

[Datura: an easily accessible hallucinogen, a poisoning to be evoked. Apropos of 10 cases]. / Le Datura: un hallucinogène facilement accessible, une intoxication à évoquer. A propos de 10 cas.

A retrospective study of ten cases of intoxication due to Datura were reported. Clinical symptoms were those of atropinic intoxication, associated with hallucinations and aggressiveness. The diagnostic is supported by clinical examination. Laboratory examinations are useful only for differential diagnosis.

[Primary torsion of the greater omentum. Apropos of a case and review of the literature]. / Torsion primitive du grand épiploon. A propos d'un cas et revue de la littérature.

The authors report about one case of acute abdominal pain syndrome, the etiology of which proved to be a primary torsion of the greater omentum. On this basis, they review the international literature and set forth etiopathogenetic hypotheses.