RESUMO
Three male and four female mouse single-sex chimeras derived from fusions of Rb(11.13)4Bnr T(1;13)70H homozygous embryos with +/+ embryos were caged with T(1;13)70H homozygotes of the opposite sex and followed through their reproductive lifespans. Six animals (three males and three females) were germline chimeras. The fz gene was used as a marker for the T70H reciprocal translocation. The ratio of fz/fz to fz/+ offspring did not change with increasing age in males, but decreased in two of the three female chimeras. Within males, there was generally good agreement between the proportions of translocation and nontranslocation germ cells from spermatogonial mitosis through the first and second meiotic division. In one male, this ratio was also reflected in the offspring. In the other two males, there was significant selection during haplophase, from which both types of spermatozoa could benefit.
Assuntos
Quimera/genética , Fertilidade/genética , Translocação Genética , Animais , Feminino , Homozigoto , Masculino , Camundongos , Espermatogônias/citologia , Cromossomo X , Cromossomo YRESUMO
Extensive localized bone resorption within the femur was observed after four total hip replacements. The amount and location of the resorption suggested the presence of infection or tumor, but there was no evidence of either condition and the roentgenographic appearance differed from that associated with a loose uncemented endoprosthesis or a grossly loose femoral component of a total hip replacement. At reoperation the femoral components were not rigidly fixed but were only slightly loose. Histologically there were sheets of macrophages, a few giant cells, and multiple small fragments of a birefringent material, but no inflammatory cells. While the exact mechanism of this serious complication is unclear, the findings suggest that a benign, non-inflammatory, adverse tissue response can occur in relation to the femoral components of total hip replacements that are not rigidly fixed. In all four hips, reimplantation of a new total hip replacement was successful after follow-up of thirteen to eighteen months.
