RESUMO
INTRODUCTION: Human milk oligosaccharides (HMOs) are important components of human milk having diverse functions in the development of infants. Randomized controlled trials (RCTs) have demonstrated that infant formulas with the HMOs 2'-fucosyllactose (2'FL) and lacto-N-neotetraose (LNnT) are safe, well-tolerated, and support normal growth. This study aimed to generate real-world evidence (RWE) on growth and gastrointestinal (GI) tolerance in infants consuming a formula with 1 g/L 2'FL and 0.5 g/L LNnT, including a mixed feeding group not studied before in RCTs. PARTICIPANTS AND METHODS: This 8-week open-label prospective multicenter study was conducted in Germany and Austria, and included groups of healthy, exclusively breastfed infants (BF), exclusively formula-fed infants (FF) who received the HMO-formula, and infants mixed fed with both HMO formula and human milk (MF). Co-primary outcomes were anthropometry and gastrointestinal tolerance via validated Infant Gastrointestinal Symptom Questionnaire (IGSQ). Secondary outcomes included formula satisfaction and adverse events (AEs). RESULTS: One-hundred six infants completed the study (46 FF, 22 MF, and 38 BF). Mean anthropometric z-scores were comparable between groups and generally within ± 0.5 of WHO medians at week 8. IGSQ composite scores demonstrated good GI tolerance in all groups with no significant group differences at week 4 or 8. IGSQ composite scores in FF improved during the course of the study and parents provided high satisfaction ratings for the HMO-formula. Four potentially product-related AEs were reported in FF (no in MF). CONCLUSIONS: In this RWE study examining an infant formula with HMOs, growth and GI tolerance outcomes were confirming the good tolerance and safety of this early feeding option previously reported in RCTs.
RESUMO
We report on the design, fabrication, and implementation of grating-waveguide structures (GWS) for intracavity polarization and wavelength selection as well as wavelength tuning. The GWS discussed in this Letter is a combination of a low-index leaky-mode waveguide, a subwavelength diffraction grating, and a highly reflective mirror that was designed to operate in Littrow configuration. Using our device as the end mirror of an Yb:YAG thin-disk laser allowed the extraction of beams that exhibit an extremely narrow laser emission bandwidth of ≈25 pm FWHM and a high degree of linear polarization of 99±0.5%. Moreover, the GWS allows a wavelength tuning range from 1007 to 1053 nm. The high-power suitability and the low loss of the GWS was demonstrated by the intracavity use in an Yb:YAG thin-disk laser with an output power of 325 W in multimode operation (M(2)=6) and with 110 W in fundamental-mode operation (M(2)≈1.2), exhibiting optical efficiencies of 53.2% and 36.2%, respectively. An output power of 1.8 kW, corresponding to a power density of 125 kW/cm(2) on the grating, was achieved in further higher-power experiments.
