[Combination of aminoglutethimide and polychemotherapy for the treatment of predominant bone metastasis in breast cancer]. / Kombination von Aminoglutethimid und Polychemotherapie zur Behandlung von dominanter Knochenmetastasierung des Mammakarzinoms.

A clinical phase II study was performed to evaluate the therapeutic efficacy of simultaneously administered aminoglutethimide and polychemotherapy in 31 patients with predominant bone metastases of breast cancer. The majority of patients was postmenopausal and pretreated with hormones and (or) chemotherapy. In 28 evaluable patients an overall objective response rate of 61% was achieved. Patients who received aminoglutethimide and polychemotherapy containing anthracyclines as FAC- or AV-regimen showed the highest objective response rate (67%). Thus, simultaneous combination of aminoglutethimide and polychemotherapy containing anthracycline derivatives is the most effective therapeutic regimen for those patients who were either pretreated or have progressive bone metastases with confinement to bed or have concomitant visceral metastases.

[Laparoscopic tubal sterilization. Methods, indications, results of 500 interventions]. / Die laparoskopische Tubensterilisation. Methoden, Indikationen, Ergebnisse bei 500 Eingriffen

PIP: Indications for laparoscopic tubal sterilization can include physiological or psychological problems, somatic damage due to ovualtion inhibitors, side effects or intolerability of the pill, or medical, genetic, or social considerations. Contraindications include serious heart and circulatory disturbances, heart infarctions, and conditions prohibiting the patient from remaining in a position with raised pelvis. Previous laparotomies are not considered contraindications in spite of the slightly higher risk element. Possible complications may be damage to the blood vessels, intestinal perforations, anasthetic complications, gas embolisms, and after-bleeding. The Frangenheim and Palmer methods, now used throughout the world, are simple and practical, although the skill and care of the physician are still extremely important. In search of even safer methods, clinics have been experimenting with tubal sterilization via bicoagulation, which benefits from more precise control of the electrical stream, and reduction of the voltage to 1/10 of the usual. In 500 laparoscopic tubal sterilizations performed in a Duisburg clinic since 1973 there were no failures and no serious complications. Before the operation married couples were counseled concerning the irreversibility of theprocedure, and their written permission was obtained.^ieng