RESUMO
The effect of chronic methadone treatment upon the serum levels of Estradiol (E2), Progesterone (P), Prolactin (Prl), monkey chorionic gonadotropin (mCG), dehydroepiandrosterone sulfate (DHEAS) and Cortisol (C) in pregnant Cynomolgus monkeys (Macaca fascicularis) is described in comparison with the hormone levels in a control group. Only DHEAS was significantly decreased in late pregnancy in the methadone group. From these data it can not be concluded that methadone treatment compromises (feto)placental function. The observed intra-uterine growth retardation in the methadone treated group might be a result of a direct influence of methadone upon growth.
Assuntos
Peso ao Nascer/efeitos dos fármacos , Desidroepiandrosterona/sangue , Metadona/efeitos adversos , Prenhez/efeitos dos fármacos , Animais , Gonadotropina Coriônica/sangue , Estradiol/sangue , Feminino , Retardo do Crescimento Fetal/etiologia , Hidrocortisona/sangue , Macaca fascicularis , Gravidez , Progesterona/sangueRESUMO
Serum levels of estradiol (E2), progesterone (P), prolactin (Prl), monkey chorionic gonadotropin (mCG), dehydroepiandrosterone sulfate (DHEAS), and cortisol (C) in pregnant cynomolgus monkeys are described. mCG, E2, and Prl patterns resembled those of pregnant rhesus monkeys. P patterns differed from data from the literature. DHEAS patterns did not follow E2 patterns. C levels did not change during pregnancy.
Assuntos
Hormônios/sangue , Macaca fascicularis/sangue , Macaca/sangue , Prenhez/sangue , Animais , Gonadotropina Coriônica/sangue , Desidroepiandrosterona/análogos & derivados , Desidroepiandrosterona/sangue , Sulfato de Desidroepiandrosterona , Estradiol/sangue , Feminino , Hidrocortisona/sangue , Gravidez , Progesterona/sangue , Prolactina/sangue , Valores de ReferênciaRESUMO
A generally accepted management of heroin addiction during pregnancy is treatment with methadone, which reduces the complications of heroin addiction considerably. Reports in the literature are still contradictory, however, about the influence of methadone upon birthweight. In pregnant Cynomolgus monkeys (Macaca fascicularis) the effect of chronic treatment with rather high dosages of methadone upon birthweight was studied under standardized conditions. Birthweights were significantly lower in the methadone-treated animals.