RESUMO
Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental work (information processing and logical problem solving). The degree of fatigue was evaluated before and after exercise by the HAM (Health status-Activity-Moods) and AMF (Acute Mental Fatigue) questionnaires. A significant relationship between the DAT1, DRD2, and COMT gene polymorphism and changes in the mental sphere status were revealed. The effects of these polymorphisms were the most pronounced in girls. The results are discussed within the framework of hypothesis on the effects of changes in the phasic/tonic dopamine proportion on the studied functions.
Assuntos
Catecol O-Metiltransferase/genética , Proteínas da Membrana Plasmática de Transporte de Dopamina/genética , Variação Genética , Fadiga Mental/fisiopatologia , Receptores de Dopamina D2/genética , Primers do DNA/genética , Feminino , Humanos , Masculino , Fadiga Mental/genética , Reação em Cadeia da Polimerase , Fatores Sexuais , Inquéritos e Questionários , Adulto JovemRESUMO
In order to test the "serotonin" hypothesis of the genesis of central fatigue, we studied association between genotype and fatigue (3-hour mental workload consisting of information processing and logical task solution) using analysis of variance for different indices (well-being, activity, mood, mental fatigue index). It was concluded that young men with serotonin deficit (LL genotype) and girls with serotonin excess (S genotype) were less tolerant to long-lasting mental workload. Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter.
Assuntos
Fadiga/genética , Processos Mentais , Polimorfismo Genético , Proteínas da Membrana Plasmática de Transporte de Serotonina/genética , Caracteres Sexuais , Afeto , Alelos , Análise de Variância , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Testes Psicológicos , Inquéritos e Questionários , Adulto JovemRESUMO
Genetic and psychological analysis of the relationships between catechol-O-methyltransferase Val158Met polymorphism and various types of aggressiveness was performed in 114 women. Dispersion analysis revealed significant association of ValVal genotype with elevated physical aggression.
Assuntos
Agressão , Catecol O-Metiltransferase/genética , Polimorfismo de Nucleotídeo Único , Adolescente , Criança , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Metionina/genética , Personalidade/genética , Valina/genética , Adulto JovemRESUMO
Associations of functional polymorphism in genes of dopamine receptor DRD2, dopamine transporter DAT, and dopamine degrading enzyme COMT with variations in anxiety sensitivity threshold were studied. On the basis of genetic and psychological analysis, an attempt was undertaken to evaluate the relationship of DRD2, DAT and COMT genotypes with values obtained using different anxiety scales. It was found that carriers of VA1(+)9(+) genotype exhibit increased anxiety and significantly differed from individuals with other genotypes. The results were illustrated with model of dopamine diffusion in the extracellular space of the striatum in carriers of different genotypes.
