1.
Org Lett
; 7(19): 4095-7, 2005 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16146360
RESUMO
[reaction: see text] A new route to the key coupling partner, chloromethylated CoQ0 (1), allows for direct formation of CoQ10 (3) via nickel-catalyzed cross-coupling with the side chain in the form of an in situ-derived vinyl alane (2).
Assuntos
Ubiquinona/análogos & derivados , Alcenos/síntese química , Alcenos/química , Alquilação , Alcinos/química , Coenzimas , Estrutura Molecular , Tolueno/análogos & derivados , Tolueno/química , Compostos de Trimetilsilil/química , Ubiquinona/síntese química , Ubiquinona/química
2.
Angew Chem Int Ed Engl
; 37(11): 1566-1569, 1998 Jun 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29710915
RESUMO
Fixed on an aromatic platform in a conformationally defined way, acyclic (E)-alkenes can be considered gripped on a molecular workbench. The olefinic ansa-macrolides formed in this way are shielded on one face. On epoxidation and dihydroxylation [Eq. (1)] the attack on the double bond takes place diastereoselectively from outside the ring, and the ansa chain can subsequently be cleaved from the workbench by mild hydrogenolysis. Bn=benzyl, NMO=N-methylmorpholin-N-oxide.