Validation of a novel image-weighed technique for monitoring food intake and estimation of portion size in hospital settings: a pilot study.

OBJECTIVE: Optimal nutrition for hospital patients is crucial and routine monitoring of patients' nutrient intake is imperative. However, personalised monitoring and customised intervention using traditional methods is challenging and labour-intensive, consequently it is often neglected in hospital settings. The present pilot study aimed to examine the reliability and validity of the Dietary Intake Monitoring System (DIMS) against the weighed food method (WFM). DESIGN: The DIMS 2.0 is composed of an integrated digital camera, weighing scale, radio-frequency identification sensor and WIFI connection for real-time image and weight dietary data acquisition and analysis. The DIMS equipment was used to collect data for a paired set of meals both before and after meal consumption at lunchtime. SETTING: Odense University Hospital, Denmark. SUBJECTS: Photos and weights of seventeen patient meals were captured. RESULTS: The results showed a significant correlation between DIMS and WFM for energy (r=0·99, P<0·01) and protein intake (r=0·98, P<0·01). Intraclass correlation coefficients (ICC) revealed a high degree of agreement among the four non-trained assessors for estimates of portion size of each food item before (0·88, P<0·01) and after consumption (0·99, P<0·01). The ICC for energy and protein intake were 0·99 (P<0·01) and 0·99 (P<0·01), respectively. Bland-Altman plots revealed no systematic bias. CONCLUSIONS: Considering the huge benefits associated with routine monitoring, technological advances have made it possible to develop a novel, easy-to-use DIMS that, according to the findings, is a valid alternative for use in hospital settings.

Transient plasma cobalamin elevation in patients with pneumonia - two case reports.

We report two cases of transient significantly elevated plasma cobalamin (B12) in geriatric patients acutely admitted with fever, increased C-reactive protein and X-ray verified pneumonia. Extensive diagnostic workup did not reveal kidney or liver disease, neither any signs of cancer. Furthermore, none of the patients had received therapeutic B12 supplementation prior to admission. In both cases, plasma B12 normalized at an out-patient control few months later. We were not able to identify the reason for the initial B12 elevation in any of the patients, since none of the usually recognized causes were evident. Since both patients had an infection and temporarily elevated B12, we suggest a possible inflammatory response or a vitamin B12 production by the infectious agents as the cause. Both suggestions, however, need further exploration.

How to measure energy and protein intake in a geriatric department - A comparison of three visual methods.

BACKGROUND & AIMS: Sufficient energy and protein intake are essential to treatment and recovery of hospitalized older adults. The food intake should be assessed in order to detect patients in need of nutritional intervention. The aim of this study was to compare the accuracy of three visual methods for assessing energy and protein intake as compared to weighing food items. METHODS: We conducted assessment of 103 lunch meals served to geriatric inpatients. Lunch meals were assessed by the nursing staff using three visual methods: 1. Meal Portions (MP): Consumption of each meat/fish, vegetables, potatoes, and sauce 2. Plate Method (PM): Consumption of 100%, 75%, 50%, 25%, or 0% 3. Reduced Plate Method (RPM): All, half, quarter, or nothing Separate weighing of all food items pre- and post-serving was used as reference method. Wilcoxon Signed Rank Test was used comparing the accuracy of the three visual methods. Bland-Altman analysis was used to test the degree of agreement. Results are given as median estimates [25%>, 75%> percentiles]. The Alpha level was set to 0.05. RESULTS: The total energy served pr. lunch meal was 893.6 kJ [830.4, 1034.3] and the weighed intake 676.6 kJ [421.4, 870.0]. The median intake was 663.0 kJ [389.0, 873.0] (p = 0.044), 636.0 kJ [436.5, 873.0] (p < 0.001), and 487.8 kJ [316.5, 873.0] (p < 0.001) assessed by MP, PM, and RPM respectively. The weighted protein content pr. served meal was 13.0 g [11.4, 15.4] with a weighted intake of 10.3 g [5.3, 13.1]. The median intake was 10.7 g [5.3, 11.7] (P = 0.045), 9.3 g [5.8, 11.7] (p < 0.001), and 8.0 g [4.8, 11.7] (p < 0.001) assessed by MP, PM, and RPM respectively. CONCLUSIONS: All visual methods underestimated energy intake. PM and RPM underestimated protein intake whereas MP overestimated protein intake. However, visual assessment by MP was found to be most accurate.

Birth prevalence and mutation spectrum in danish patients with autosomal recessive albinism.

PURPOSE: The study was initiated to investigate the mutation spectrum of four OCA genes and to calculate the birth prevalence in patients with autosomal recessive albinism. METHODS: Mutation analysis using dHPLC or direct DNA sequencing of TYR, OCA2, TYRP1, and MATP was performed in 62 patients. Furthermore, 15 patients were investigated for mutations in SLC24A5. Allele expression was investigated in heterozygous patients by RT-PCR analysis. The birth prevalence was calculated based on retrospective data from a compulsory national register. RESULTS: Sixty-two patients were investigated for mutations. Two mutations in one OCA gene explained oculocutaneous albinism (OCA) in 44% of the patients. Mutations in TYR were found in 26% of patients, while OCA2 and MATP caused OCA in 15% and 3%, respectively. No mutations were found in TYRP1. Of the remaining 56% of patients, 29% were heterozygous for a mutation in either TYR or OCA2, and 27% were without mutations in any of the four genes. Exclusive expression of the mutant allele was found in four heterozygous patients. A minimum birth prevalence of 1 in 14,000 was calculated, based on register data on 218 patients. The proportion of OCA to autosomal recessive ocular albinism (AROA) based on clinical findings was 55 to 45. CONCLUSIONS: TYR is the major OCA gene in Denmark, but several patients do not have mutations in the investigated genes. A relatively large fraction of patients were observed with AROA, and of those 52% had no mutations compared with 15% of those with OCA.